Tuesday’s MLB Odds, Betting Lines and Predictions - Sept. 22

There is no shortage of excitement on today's MLB schedule, including the Milwaukee Brewers squaring off against the Philadelphia Phillies. Take a look at at the article below, where we provide predictions for each game.

Today's MLB Odds and Predictions

Tampa Bay Rays at New York Yankees Odds, Lines & Predictions

Game Info

• When: 1:05 p.m. ET
• Where: Yankee Stadium
• TV Channel: YES and RAYS
• Probable Pitchers: Carlos Rodon vs. Nick Martínez
• Records: Yankees (90-66), Rays (95-61)
• Yankees Moneyline Odds: -142
• Rays Moneyline Odds: +120

numberFire Prediction

• numberFire Predicted Favorite: Yankees
• Yankees Win Probability: 55.00%
• Rays Win Probability: 45.00%

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Washington Nationals at Detroit Tigers Odds, Lines & Predictions

Game Info

• When: 6:40 p.m. ET
• Where: Comerica Park
• TV Channel: DSN and NATS
• Probable Pitchers: Drew Anderson vs. Riley Cornelio
• Records: Tigers (74-83), Nationals (73-84)
• Tigers Moneyline Odds: -152
• Nationals Moneyline Odds: +128

numberFire Prediction

• numberFire Predicted Favorite: Tigers
• Tigers Win Probability: 57.02%
• Nationals Win Probability: 42.98%

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St. Louis Cardinals at Pittsburgh Pirates Odds, Lines & Predictions

Game Info

• When: 6:40 p.m. ET
• Where: PNC Park
• TV Channel: SportsNet PT and CARD
• Probable Pitchers: Jared Jones vs. Andre Pallante
• Records: Pirates (80-77), Cardinals (76-81)
• Pirates Moneyline Odds: -178
• Cardinals Moneyline Odds: +150

numberFire Prediction

• numberFire Predicted Favorite: Pirates
• Pirates Win Probability: 59.30%
• Cardinals Win Probability: 40.70%

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Milwaukee Brewers at Philadelphia Phillies Odds, Lines & Predictions

Game Info

• When: 6:40 p.m. ET
• Where: Citizens Bank Park
• TV Channel: NBCS-PH and BREW
• Probable Pitchers: Zack Wheeler vs. Dustin May
• Records: Phillies (86-70), Brewers (98-58)
• Phillies Moneyline Odds: -152
• Brewers Moneyline Odds: +128

numberFire Prediction

• numberFire Predicted Favorite: Brewers
• Brewers Win Probability: 50.58%
• Phillies Win Probability: 49.42%

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Cleveland Guardians at Boston Red Sox Odds, Lines & Predictions

Game Info

• When: 6:45 p.m. ET
• Where: Fenway Park
• TV Channel: NESN and CLEG
• Probable Pitchers: Payton Tolle vs. Parker Messick
• Records: Red Sox (84-72), Guardians (81-75)
• Red Sox Moneyline Odds: -120
• Guardians Moneyline Odds: +102

numberFire Prediction

• numberFire Predicted Favorite: Red Sox
• Red Sox Win Probability: 56.62%
• Guardians Win Probability: 43.38%

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Tampa Bay Rays at New York Yankees Odds, Lines & Predictions

Game Info

• When: 7:05 p.m. ET
• Where: Yankee Stadium
• TV Channel: TBS and YES and RAYS
• Probable Pitchers: Max Fried vs. Drew Rasmussen
• Records: Yankees (90-66), Rays (95-61)
• Yankees Moneyline Odds: -130
• Rays Moneyline Odds: +110

numberFire Prediction

• numberFire Predicted Favorite: Yankees
• Yankees Win Probability: 50.12%
• Rays Win Probability: 49.88%

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Cincinnati Reds at Atlanta Braves Odds, Lines & Predictions

Game Info

• When: 7:15 p.m. ET
• Where: Truist Park
• TV Channel: BravesVsn and CINR
• Probable Pitchers: JR Ritchie vs. Brandon Williamson
• Records: Braves (92-64), Reds (72-84)
• Braves Moneyline Odds: -230
• Reds Moneyline Odds: +190

numberFire Prediction

• numberFire Predicted Favorite: Braves
• Braves Win Probability: 66.89%
• Reds Win Probability: 33.11%

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Chicago White Sox at Kansas City Royals Odds, Lines & Predictions

Game Info

• When: 7:40 p.m. ET
• Where: Kauffman Stadium
• TV Channel: ROYL and CHSN
• Probable Pitchers: Daniel Lynch vs. Anthony Kay
• Records: Royals (67-89), White Sox (80-76)
• White Sox Moneyline Odds: -118
• Royals Moneyline Odds: +100

numberFire Prediction

• numberFire Predicted Favorite: Royals
• Royals Win Probability: 51.70%
• White Sox Win Probability: 48.30%

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Miami Marlins at Chicago Cubs Odds, Lines & Predictions

Game Info

• When: 7:40 p.m. ET
• Where: Wrigley Field
• TV Channel: MARQ and MIAM
• Probable Pitchers: Shota Imanaga vs. Janson Junk
• Records: Cubs (87-69), Marlins (76-80)
• Cubs Moneyline Odds: -200
• Marlins Moneyline Odds: +168

numberFire Prediction

• numberFire Predicted Favorite: Cubs
• Cubs Win Probability: 62.27%
• Marlins Win Probability: 37.73%

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New York Mets at Texas Rangers Odds, Lines & Predictions

Game Info

• When: 8:05 p.m. ET
• Where: Globe Life Field
• TV Channel: RSN and SNY
• Probable Pitchers: MacKenzie Gore vs. Sean Manaea
• Records: Rangers (78-78), Mets (71-85)
• Rangers Moneyline Odds: -126
• Mets Moneyline Odds: +108

numberFire Prediction

• numberFire Predicted Favorite: Rangers
• Rangers Win Probability: 53.75%
• Mets Win Probability: 46.25%

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Arizona Diamondbacks at Colorado Rockies Odds, Lines & Predictions

Game Info

• When: 8:40 p.m. ET
• Where: Coors Field
• TV Channel: COLR and ARID
• Probable Pitchers: Kyle Freeland vs. Mike Soroka
• Records: Rockies (57-99), Diamondbacks (82-74)
• Diamondbacks Moneyline Odds: -184
• Rockies Moneyline Odds: +154

numberFire Prediction

• numberFire Predicted Favorite: Diamondbacks
• Diamondbacks Win Probability: 60.79%
• Rockies Win Probability: 39.21%

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Houston Astros at Seattle Mariners Odds, Lines & Predictions

Game Info

• When: 9:40 p.m. ET
• Where: T-Mobile Park
• TV Channel: SEAM and SCHN
• Probable Pitchers: Logan Gilbert vs. Cristian Javier
• Records: Mariners (73-83), Astros (77-79)
• Mariners Moneyline Odds: -134
• Astros Moneyline Odds: +116

numberFire Prediction

• numberFire Predicted Favorite: Mariners
• Mariners Win Probability: 58.50%
• Astros Win Probability: 41.50%

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Los Angeles Angels at Athletics Odds, Lines & Predictions

Game Info

• When: 9:40 p.m. ET
• Where: Sutter Health Park
• TV Channel: NBCS-CA and ABTV
• Probable Pitchers: Brady Basso vs. Yusei Kikuchi
• Records: Athletics (61-95), Angels (60-96)
• Athletics Moneyline Odds: -108
• Angels Moneyline Odds: -108

numberFire Prediction

• numberFire Predicted Favorite: Athletics
• Athletics Win Probability: 57.43%
• Angels Win Probability: 42.57%

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Minnesota Twins at San Francisco Giants Odds, Lines & Predictions

Game Info

• When: 9:45 p.m. ET
• Where: Oracle Park
• TV Channel: NBCS-BA and MNNT
• Probable Pitchers: Anthony Molina vs. Taj Bradley
• Records: Giants (65-92), Twins (73-84)
• Twins Moneyline Odds: -142
• Giants Moneyline Odds: +120

numberFire Prediction

• numberFire Predicted Favorite: Twins
• Twins Win Probability: 50.18%
• Giants Win Probability: 49.82%

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San Diego Padres at Los Angeles Dodgers Odds, Lines & Predictions

Game Info

• When: 10:10 p.m. ET
• Where: Dodger Stadium
• TV Channel: TBS and SportsNet LA and SDPA
• Probable Pitchers: Brock Stewart vs. Michael King
• Records: Dodgers (96-60), Padres (87-69)
• Dodgers Moneyline Odds: -130
• Padres Moneyline Odds: +110

numberFire Prediction

• numberFire Predicted Favorite: Dodgers
• Dodgers Win Probability: 59.41%
• Padres Win Probability: 40.59%

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All MLB win probability predictions and picks are according to numberFire.