Mississippi State vs Missouri Prediction, Odds, Picks, Best Bets for Week 4 2026

The Mississippi State Bulldogs are among the college football squads playing on Saturday, up against the Missouri Tigers.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital information about today's NCAA football betting odds.

Mississippi State vs Missouri Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Mississippi State: (-200) | Missouri: (+164)
• Spread: Mississippi State: -4.5 (-110) | Missouri: +4.5 (-110)
• Total: 58.5 -- Over: (-106) | Under: (-114)

Mississippi State vs Missouri Betting Trends

• Mississippi State is 3-0-0 against the spread this year.
• Mississippi State is unbeaten ATS (1-0) as a 4.5-point favorite or greater this season.
• Two of three Mississippi State games have hit the over this year.
• Missouri has posted one win against the spread this year.
• Two Missouri games (of three) have hit the over this year.

Mississippi State vs Missouri Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Bulldogs win (61.6%)

Mississippi State vs Missouri Point Spread

Missouri is listed as an underdog by 4.5 points (-110 odds), and Mississippi State, the favorite, is -110 to cover.

Mississippi State vs Missouri Over/Under

The over/under for the Mississippi State versus Missouri game on Sept. 26 has been set at 58.5, with -106 odds on the over and -114 odds on the under.

Mississippi State vs Missouri Moneyline

The Mississippi State vs Missouri moneyline has Mississippi State as a -200 favorite, while Missouri is a +164 underdog.

Mississippi State vs. Missouri Points Insights

Mississippi State vs. Missouri Game Info

• Game day: Saturday, September 26, 2026
• Game time: 7:45 p.m. ET
• TV channel: SEC Network
• Location: Starkville, Mississippi
• Stadium: Davis Wade Stadium at Scott Field

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Check out even more in-depth Mississippi State vs. Missouri analysis on FanDuel Research.