Michigan State vs Eastern Michigan Prediction, Odds, Picks, Best Bets for Week 2 2026

The Michigan State Spartans are among the college football squads playing on Saturday, up against the Eastern Michigan Eagles.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Michigan State vs Eastern Michigan Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Michigan State: (-1000) | Eastern Michigan: (+640)
• Spread: Michigan State: -17.5 (-106) | Eastern Michigan: +17.5 (-114)
• Total: 49.5 -- Over: (-110) | Under: (-110)

Michigan State vs Eastern Michigan Betting Trends

• Michigan State hasn't won a game against the spread this season.
• Michigan State has had one game (of one) go over the total this year.
• Eastern Michigan has posted one win against the spread this year.
• Eastern Michigan and its opponent have yet to go over the total this year.

Michigan State vs Eastern Michigan Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Spartans win (85.7%)

Michigan State vs Eastern Michigan Point Spread

Michigan State is favored by 17.5 points over Eastern Michigan. Michigan State is -106 to cover the spread, with Eastern Michigan being -114.

Michigan State vs Eastern Michigan Over/Under

Michigan State versus Eastern Michigan on Sept. 12 has an over/under of 49.5 points, with the over -110 and the under -110.

Michigan State vs Eastern Michigan Moneyline

Eastern Michigan is a +640 underdog on the moneyline, while Michigan State is a -1000 favorite.

Michigan State vs. Eastern Michigan Points Insights

• The average implied total for the Spartans last season was 31.3 points, 2.7 fewer points than their implied total of 34 points in Saturday's game.
• The Eagles' average implied point total last season (31.0 points) is 15.0 points higher than their implied total in this matchup (16 points).

Michigan State vs. Eastern Michigan Game Info

• Game day: Saturday, September 12, 2026
• Game time: 3:30 p.m. ET
• TV channel: BTN
• Location: East Lansing, Michigan
• Stadium: Spartan Stadium

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Check out even more in-depth Michigan State vs. Eastern Michigan analysis on FanDuel Research.