Matthew Stafford Fantasy Football Week 10: Stats and Projections vs. 49ers

In Week 10 (Sunday at 4:25 p.m. ET), QB Matthew Stafford and the Los Angeles Rams will play the San Francisco 49ers, who have the 21st-ranked passing defense in the NFL (223.7 yards conceded per game).

For more details on Stafford, if you're considering him for your DFS lineup, scroll down before his upcoming game against the 49ers.

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Matthew Stafford Week 10 Fantasy Football Projection

• Matchup: Los Angeles Rams at San Francisco 49ers
• Game Date: November 9, 2025
• Game Time: 4:25 p.m.
• Projected Fantasy Points: 18.0
• Projected Passing Yards: 271.88
• Projected Passing TDs: 2.01
• Projected Rushing Yards: 4.61
• Projected Rushing TDs: 0.05

Projections provided by numberFire

Stafford Fantasy Performance

• Among players at the QB position, Stafford is currently the ninth-ranked player in fantasy (11th overall), with 161.2 total fantasy points (20.2 per game).
• In his last three games, Stafford has put up 63.5 fantasy points (21.2 per game), completing 62-of-91 passes for 644 yards, 10 touchdowns, and zero interceptions. He's added -2 rushing yards on 10 carries.
• Stafford has tallied 116.5 fantasy points (23.3 per game) in his last five games, as he's amassed 1,408 yards on 121-of-179 passing, with 16 touchdowns and zero picks. As a runner, he's tacked on two rushing yards on 15 carries.
• The peak of Stafford's fantasy season came against the Jacksonville Jaguars in Week 7, when he racked up 27.4 fantasy points with 182 passing yards, five TDs, and zero picks.
• From a fantasy perspective, Matthew Stafford's game against the Baltimore Ravens in Week 6 was his worst of the year, as he posted 9.3 fantasy points. He passed for 181 yards and one touchdown, and threw zero picks on the day.

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49ers Defensive Performance

• San Francisco has given up more than 300 yards passing to two players this season.
• A total of Eight players have thrown for at least one TD against the 49ers this year.
• A total of five players have thrown for two or more TDs against San Francisco this season.
• Two players have passed for at least three TDs in a game against the 49ers this year.
• A total of one player has put up more than 100 yards receiving in a game versus San Francisco this year.
• The 49ers have allowed a TD catch by 14 players this year.
• Only one player has caught more than one TD pass versus San Francisco this season.
• The 49ers have allowed only one player to rack up more than 100 yards rushing in a game this season.
• San Francisco has allowed five players to score at least one rushing touchdown against them this season.
• No player has run for more than one touchdown versus the 49ers this year.

Want more data and analysis on Matthew Stafford? Check out FanDuel Research for all the latest and in-depth fantasy and betting coverage.