LSU vs Clemson Prediction, Odds, Picks, Best Bets for Week 1 2026

College football's Saturday schedule includes the LSU Tigers taking on the Clemson Tigers.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

LSU vs Clemson Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LSU: (-400) | Clemson: (+315)
• Spread: LSU: -10.5 (-104) | Clemson: +10.5 (-118)
• Total: 50.5 -- Over: (-105) | Under: (-115)

LSU vs Clemson Betting Trends

• LSU was 4-9-0 against the spread last season.
• LSU went winless ATS (0-3) when playing as at least 10.5-point favorites last season.
• Out of 13 LSU games last year, four hit the over.
• Clemson had five wins in 13 games against the spread last year.
• In 13 Clemson games last year, four of them went over the total.

LSU vs Clemson Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Tigers win (66.7%)

LSU vs Clemson Point Spread

LSU is favored by 10.5 points over Clemson. LSU is -104 to cover the spread, with Clemson being -118.

LSU vs Clemson Over/Under

The over/under for the LSU versus Clemson matchup on Sept. 5 has been set at 50.5, with -105 odds on the over and -115 odds on the under.

LSU vs Clemson Moneyline

LSU is a -400 favorite on the moneyline, while Clemson is a +315 underdog.

LSU vs. Clemson Points Insights

• The LSU Tigers' average implied point total last season was 0.4 more points than their implied total in Saturday's game (31.4 implied points on average compared to 31 implied points in this game).
• The Clemson Tigers' average implied point total last season (31.6 points) is 11.6 points higher than their implied total in this matchup (20 points).

LSU vs. Clemson Game Info

• Game day: Saturday, September 5, 2026
• Game time: 7:30 p.m. ET
• TV channel: ABC
• Location: Baton Rouge, Louisiana
• Stadium: Tiger Stadium

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Check out even more in-depth LSU vs. Clemson analysis on FanDuel Research.