Louisville vs SMU Prediction, Odds, Picks, Best Bets for Week 3 2026

On Saturday in college football, the Louisville Cardinals are up against the SMU Mustangs.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Louisville vs SMU Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Louisville: (-122) | SMU: (+102)
• Spread: Louisville: -1.5 (-112) | SMU: +1.5 (-108)
• Total: 58.5 -- Over: (-110) | Under: (-110)

Louisville vs SMU Betting Trends

• Louisville has two wins against the spread this season.
• Louisville is unbeaten ATS (1-0) as a 1.5-point favorite or greater this season.
• Two of Louisville's two games have hit the over.
• SMU has posted one win against the spread this year.
• One SMU game (out of two) has hit the over this year.

Louisville vs SMU Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (69.9%)

Louisville vs SMU Point Spread

Louisville is favored by 1.5 points over SMU. Louisville is -112 to cover the spread, with SMU being -108.

Louisville vs SMU Over/Under

An over/under of 58.5 has been set for Louisville-SMU on Sept. 19, with the over being -110 and the under -110.

Louisville vs SMU Moneyline

The Louisville vs SMU moneyline has Louisville as a -122 favorite, while SMU is a +102 underdog.

Louisville vs. SMU Points Insights

Louisville vs. SMU Game Info

• Game day: Saturday, September 19, 2026
• Game time: 3:30 p.m. ET
• TV channel: ESPN2
• Location: Louisville, Kentucky
• Stadium: L&N Federal Credit Union Stadium

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Check out even more in-depth Louisville vs. SMU analysis on FanDuel Research.