Louisville vs SMU Prediction, Odds, Picks, Best Bets for Week 3 2026

Saturday's slate in college football includes a matchup between the Louisville Cardinals and the SMU Mustangs.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Louisville vs SMU Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Louisville: (-126) | SMU: (+105)
• Spread: Louisville: -1.5 (-115) | SMU: +1.5 (-105)
• Total: 59.5 -- Over: (-105) | Under: (-115)

Louisville vs SMU Betting Trends

• Louisville hasn't lost a game against the spread this season.
• Louisville has covered every time (1-0) as a 1.5-point favorite or greater this year.
• Louisville and its opponent have not failed to hit the over in any game this season.
• SMU has but one win versus the spread this season.
• One of SMU's two games has gone over the point total.

Louisville vs SMU Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (57.6%)

Louisville vs SMU Point Spread

SMU is a 1.5-point underdog against Louisville. SMU is -105 to cover the spread, and Louisville is -115.

Louisville vs SMU Over/Under

A total of 59.5 points has been set for the Louisville-SMU matchup on Sept. 19, with the over available at -105 and the under at -115.

Louisville vs SMU Moneyline

SMU is a +105 underdog on the moneyline, while Louisville is a -126 favorite.

Louisville vs. SMU Points Insights

Louisville vs. SMU Game Info

• Game day: Saturday, September 19, 2026
• Game time: 3:30 p.m. ET
• TV channel: ESPN2
• Location: Louisville, Kentucky
• Stadium: L&N Federal Credit Union Stadium

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Check out even more in-depth Louisville vs. SMU analysis on FanDuel Research.