Louisville vs NC State Prediction, Odds, Picks, Best Bets for Week 5 2026

NCAA football action on Saturday includes the Louisville Cardinals playing the NC State Wolfpack.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Louisville vs NC State Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Louisville: (-160) | NC State: (+132)
• Spread: Louisville: -3.5 (100) | NC State: +3.5 (-122)
• Total: 55.5 -- Over: (-114) | Under: (-106)

Louisville vs NC State Betting Trends

• Against the spread, Louisville is 3-1-0 this year.
• Louisville has won once ATS (1-1) as a 3.5-point or higher favorite this season.
• There have been three Louisville games (of four) that went over the total this season.
• NC State has posted one win against the spread this season.
• NC State doesn't have a win ATS (0-2) as a 3.5-point underdog or greater this year.
• This year, three of NC State's four games have hit the over.

Louisville vs NC State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (51.3%)

Louisville vs NC State Point Spread

Louisville is favored by 3.5 points over NC State. Louisville is +100 to cover the spread, with NC State being -122.

Louisville vs NC State Over/Under

A total of 55.5 points has been set for the Louisville-NC State matchup on Oct. 3, with the over available at -114 and the under at -106.

Louisville vs NC State Moneyline

Looking at the moneyline for Louisville-NC State, Louisville is the favorite at -160, and NC State is +132.

Louisville vs. NC State Points Insights

Louisville vs. NC State Game Info

• Game day: Saturday, October 3, 2026
• Game time: 3:30 p.m. ET
• TV channel: ACC Network
• Location: Raleigh, North Carolina
• Stadium: Wayne Day Family Field at Carter-Finley Stadium

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Louisville vs. NC State analysis on FanDuel Research.