Louisville vs Kentucky Prediction, Odds, Picks, Best Bets for Week 14 2025

The Louisville Cardinals versus the Kentucky Wildcats is on the college football schedule for Saturday.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Louisville vs Kentucky Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Louisville: (-138) | Kentucky: (+118)
• Spread: Louisville: -2.5 (-114) | Kentucky: +2.5 (-106)
• Total: 46.5 -- Over: (-115) | Under: (-105)

Louisville vs Kentucky Betting Trends

• Louisville's record against the spread is 3-8-0.
• As at least a 2.5-point favorite, Louisville has two wins ATS (2-7).
• Louisville has played 11 games this year, and five of them have hit the over.
• Kentucky is 5-6-0 against the spread this season.
• Kentucky's ATS record as 2.5-point underdogs or greater is 4-4.
• This year, seven of Kentucky's 11 games have hit the over.

Louisville vs Kentucky Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (59.4%)

Louisville vs Kentucky Point Spread

Louisville is favored by 2.5 points against Kentucky. Louisville is -114 to cover the spread, while Kentucky is -106.

Louisville vs Kentucky Over/Under

An over/under of 46.5 has been set for Louisville-Kentucky on Nov. 29, with the over being -115 and the under -105.

Louisville vs Kentucky Moneyline

Kentucky is the underdog, +118 on the moneyline, while Louisville is a -138 favorite.

Louisville vs. Kentucky Points Insights

Louisville vs. Kentucky Game Info

• Game day: Saturday, November 29, 2025
• Game time: 12 p.m. ET
• TV channel: ACC Network
• Location: Louisville, Kentucky
• Stadium: L&N Federal Credit Union Stadium

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Check out even more in-depth Louisville vs. Kentucky analysis on FanDuel Research.