Louisville vs Boston College College Basketball Prediction, Odds, Picks, Best Bets for Jan. 10

The No. 20 Louisville Cardinals (11-4, 1-2 ACC) host the Boston College Eagles (7-8, 0-2 ACC) in ACC action at KFC Yum! Center, tipping off at 12 p.m. ET on Saturday, January 10, 2026.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Louisville vs. Boston College Game Info and Odds

• Game day: Saturday, January 10, 2026
• Game time: 12 p.m. ET
• TV channel: The CW Network
• Location: Louisville, Kentucky
• Arena: KFC Yum! Center

Louisville vs. Boston College Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Louisville win (93.1%)

Read these betting insights and trends before you wager on Saturday's Louisville-Boston College spread (Louisville -21.5) or total (149.5 points).

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Louisville vs. Boston College: ATS Betting Stats and Trends

• Louisville has won nine games against the spread this season, while failing to cover six times.
• Boston College has won four games against the spread this season, while failing to cover 11 times.
• In home games, the Cardinals own a better record against the spread (6-3-0) compared to their ATS record in road games (1-3-0).
• Against the spread, the Eagles performed better at home (8-9-0) than away (3-7-0) last season.

Louisville vs. Boston College: Moneyline Betting Stats

• Louisville has been chosen as the moneyline favorite in seven games this year and has walked away with the win five times (71.4%) in those games.
• The Cardinals have yet to play a game this season with better moneyline odds than -7143.
• Boston College has compiled a 1-4 record in games it was the underdog on the moneyline (winning 20% of those games).
• The Eagles have not yet played as a moneyline underdog of +2000 or longer.
• The moneyline set for this matchup implies Louisville has a 98.6% chance of walking away with the win.

Louisville vs. Boston College Head-to-Head Comparison

• Louisville outscores opponents by 19.1 points per game (scoring 89.2 per game to rank 20th in college basketball while giving up 70.1 per contest to rank 98th in college basketball) and has a +286 scoring differential overall.
• Ryan Conwell ranks 34th in the nation with a team-leading 19.9 points per game.
• Boston College's +31 scoring differential (outscoring opponents by 2.1 points per game) is a result of putting up 69.5 points per game (316th in college basketball) while giving up 67.4 per contest (52nd in college basketball).
• Donald Hand Jr.'s team-leading 15.5 points per game rank him 235th in the nation.
• The 39.5 rebounds per game the Cardinals average rank 10th in college basketball, and are 9.5 more than the 30.0 their opponents pull down per outing.
• Sananda Fru is 206th in college basketball action with 6.7 rebounds per game to lead the Cardinals.
• The 35.5 rebounds per game the Eagles accumulate rank 74th in college basketball, 1.5 more than the 34.0 their opponents record.
• Aidan Shaw paces the Eagles with 7.2 rebounds per game (139th in college basketball).
• Louisville ranks 28th in college basketball by averaging 108.0 points per 100 possessions on offense, and defensively is 40th in college basketball, allowing 84.9 points per 100 possessions.
• The Eagles average 89.6 points per 100 possessions on offense (322nd in college basketball), and allow 87.0 points per 100 possessions (65th in college basketball).

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