Kyren Williams Fantasy Football Week 1: Stats and Projections vs. 49ers

Kyren Williams and the Los Angeles Rams will face the San Francisco 49ers -- whose run defense was ranked 11th in the league last season (107.8 yards allowed per game) -- in Week 1, on Thursday at 8:35 p.m. ET.

With Williams' next game versus the 49ers, should you think about him for your daily fantasy lineup? Scroll down for more stats and information.

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Kyren Williams Week 1 Fantasy Football Projection

• Matchup: Los Angeles Rams vs. San Francisco 49ers
• Game Date: September 10, 2026
• Game Time: 8:35 p.m.
• Projected Fantasy Points: 10.1
• PPR Projected Fantasy Points: 10.8
• Projected Rushing Yards: 59.99
• Projected Rushing TDs: 0.48
• Projected Receiving Yards: 8.44
• Projected Receiving TDs: 0.08

Projections provided by numberFire

Williams 2025 Fantasy Performance

• In 2025, Williams picked up 227.3 fantasy points (13.4 per game) -- eighth at his position, 26th in the NFL.
• Williams accumulated 23.7 fantasy points -- 21 carries, 87 yards, 2 TDs; 4 receptions, 30 yards -- in his best game last year, in Week 2 against the Chicago Bears.
• In Week 5 against the San Francisco 49ers, Williams put up 23.1 fantasy points (his second-best total last year), via these numbers: 14 carries, 65 yards; 8 receptions, 66 yards, 2 TDs.
• In his worst game of the season -- Week 12 against the Tampa Bay Buccaneers -- Williams accumulated 4.8 fantasy points. His stat line was: 12 carries, 46 yards.
• Williams collected 6.5 fantasy points -- 12 carries, 54 yards -- in his second-worst game of the season. That was in Week 7 against the Jacksonville Jaguars.

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49ers Defensive Performance

• Last year, San Francisco allowed four quarterbacks to amass over 300 passing yards in a game.
• The 49ers gave up at least one passing touchdown to 15 opposing QBs last season.
• Through the air last season, San Francisco gave up two or more passing touchdowns to 10 opposing QBs.
• In the passing game, the 49ers allowed at least three passing touchdowns to only three opposing quarterbacks last year.
• Against San Francisco last season, four players recorded more than 100 receiving yards in a game.
• Against the 49ers last season, 27 players caught a TD pass.
• Looking at pass defense, San Francisco allowed only two players to catch at least two touchdown passes against it last year.
• Looking at run D, the 49ers allowed more than 100 rushing yards to just two players last season.
• On the ground, San Francisco allowed 11 players to score at least one rushing touchdown against them last season.
• Only two players rushed for multiple TDs in a game against the 49ers last year.

Want more data and analysis on Kyren Williams? Check out FanDuel Research for all the latest and in-depth fantasy and betting coverage.