James Madison vs Old Dominion Prediction, Odds, Picks, Best Bets for Week 4 2026

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College football's Saturday schedule includes the James Madison Dukes taking on the Old Dominion Monarchs.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

James Madison vs Old Dominion Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: James Madison: (-275) | Old Dominion: (+220)
Spread: James Madison: -6.5 (-122) | Old Dominion: +6.5 (100)
Total: 42.5 -- Over: (-110) | Under: (-110)

Against the spread, James Madison is 3-0-0 this year.
James Madison has covered every time (2-0) as a 6.5-point favorite or greater this year.
One of three James Madison games have gone over the point total this season.
Old Dominion has not won a game against the spread this year.
Old Dominion doesn't have a win ATS (0-1) as a 6.5-point underdog or more this year.
Old Dominion has had one game (of three) hit the over this year.

All college football win probability predictions and picks are according to numberFire.
Prediction: Dukes win (61.3%)

James Madison is favored by 6.5 points (-122 to cover) in this matchup. Old Dominion, the underdog, is +100.

The James Madison-Old Dominion matchup on Sept. 26 has been given an over/under of 42.5 points. The over is -110 and the under is -110.

The James Madison vs Old Dominion moneyline has James Madison as a -275 favorite, while Old Dominion is a +220 underdog.

	Point Scored (PG)	Points Scored CFB Rank	Points Allowed (PG)	Points Allowed CFB Rank	Average Total	Total Games
James Madison	44.3	21	9.7	8	51.5	3
Old Dominion	23.0	112	24.7	83	49.8	3

Check out even more in-depth James Madison vs. Old Dominion analysis on FanDuel Research.

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