James Cook Fantasy Football Week 4: Stats and Projections vs. Saints

Running back James Cook is looking at a matchup versus the 14th-ranked rushing defense in the NFL (103.3 yards conceded per game) in Week 4, when his Buffalo Bills take on the New Orleans Saints, Sunday at 1 p.m. ET.

Is Cook a DFS option for you this week, as he faces the Saints? More stats and information can be found in this article, so take a look.

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James Cook Week 4 Fantasy Football Projection

• Matchup: Buffalo Bills vs. New Orleans Saints
• Game Date: September 28, 2025
• Game Time: 1 p.m.
• Projected Fantasy Points: 16.3
• PPR Projected Fantasy Points: 17.3
• Projected Rushing Yards: 90.59
• Projected Rushing TDs: 0.83
• Projected Receiving Yards: 17.62
• Projected Receiving TDs: 0.11

Projections provided by numberFire

Cook Fantasy Performance

• At the RB position, Cook has been one of the top players in fantasy, as he ranks second in the NFL with 19.8 fantasy points per game (59.5 total points). Overall, he is 12th in fantasy points.
• Last week against the Miami Dolphins, Cook produced 17.8 fantasy points, carrying the ball 19 times for 108 yards (5.7 yards per carry) with three receptions for 10 yards as a receiver.

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Saints Defensive Performance

• Not a single QB has recorded more than 300 yards passing in a game versus New Orleans this year.
• The Saints have given up at least one passing TD to three opposing QBs this year.
• New Orleans has allowed three players to pass for at least two TDs in a game this year.
• One player have thrown for at least three TDs in a game versus the Saints this season.
• New Orleans has not given up more than 100 yards receiving to an opposing player this season.
• A total of Seven players have caught a touchdown pass versus the Saints this year.
• New Orleans has not allowed more than one TD catch to an opposing player this season.
• The Saints have not given up more than 100 yards rushing to an opposing player this season.
• New Orleans has allowed one player to score at least one rushing touchdown against them this year.
• A total of One player has rushed for more than one touchdown against the Saints this season.

Want more data and analysis on James Cook? Check out FanDuel Research for all the latest and in-depth fantasy and betting coverage.