James Cook Fantasy Football Week 2: Stats and Projections vs. Lions

James Cook and the Buffalo Bills will face the Detroit Lions -- whose rushing defense was ranked 14th in the league last year (114.5 yards allowed per game) -- in Week 2, on Thursday at 8:15 p.m. ET.

With Cook's next game against the Lions, should you think about him for your daily fantasy roster? Scroll down for more stats and info.

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James Cook Week 2 Fantasy Football Projection

• Matchup: Buffalo Bills vs. Detroit Lions
• Game Date: September 17, 2026
• Game Time: 8:15 p.m.
• Projected Fantasy Points: 15.2
• PPR Projected Fantasy Points: 15.9
• Projected Rushing Yards: 93.13
• Projected Rushing TDs: 0.77
• Projected Receiving Yards: 12.07
• Projected Receiving TDs: 0.08

Projections provided by numberFire

Cook 2025 Fantasy Performance

• Cook picked up 6.9 fantasy points in his single game this year. He had 13 carries for 57 yards and zero touchdowns, plus 12 receiving yards on three catches (four targets).
• In his best performance last year, Cook finished with 33.6 fantasy points -- 19 carries, 216 yards, 2 TDs. That was in Week 8 against the Carolina Panthers.
• In Week 15 against the New England Patriots, Cook posted 29.1 fantasy points (his second-highest total last year), via these numbers: 22 carries, 107 yards, 2 TDs; 2 receptions, 4 yards, 1 TD.
• Cook accumulated 1.5 fantasy points -- 2 carries, 15 yards -- in his worst game of the season, Week 18 against the New York Jets.
• Cook picked up 4.9 fantasy points -- 15 carries, 49 yards -- in Week 5 versus the New England Patriots, his second-worst performance of the year.

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Lions Defensive Performance

• Detroit surrendered more than 300 passing yards to only three QBs last year.
• The Lions gave up at least one passing touchdown to 15 opposing QBs last season.
• Through the air last season, Detroit gave up two or more touchdown passes to 11 opposing QBs.
• Versus the Lions last year, four players threw for at least three touchdowns in a game.
• Through the air, Detroit gave up more than 100 receiving yards to six players last season.
• Against the Lions last season, 25 players caught a TD pass.
• Detroit allowed two or more receiving touchdowns through the air to six players last season.
• In the run game, one player recorded more than 100 rushing yards in a game against the Lions last season.
• In terms of run defense, Detroit gave up at least one rushing touchdown to 14 players last season.
• Just two players ran for multiple TDs in a game against the Lions last year.

Want more data and analysis on James Cook? Check out FanDuel Research for all the latest and in-depth fantasy and betting coverage.