Iowa vs Iowa State Prediction, Odds, Picks, Best Bets for Week 2 2026

The Iowa Hawkeyes will take on the Iowa State Cyclones in college football action on Saturday.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Iowa vs Iowa State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Iowa: (-649) | Iowa State: (+460)
• Spread: Iowa: -14.5 (-102) | Iowa State: +14.5 (-120)
• Total: 41.5 -- Over: (-110) | Under: (-110)

Iowa vs Iowa State Betting Trends

• Iowa has one win against the spread this year.
• Iowa has covered every time (1-0) as a 14.5-point favorite or greater this season.
• Iowa State has not won a game against the spread this year.
• No Iowa State game has gone over the point total this season.

Iowa vs Iowa State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Hawkeyes win (77.5%)

Iowa vs Iowa State Point Spread

Iowa State is the underdog by 14.5 points against Iowa. Iowa State is -102 to cover the spread, and Iowa is -120.

Iowa vs Iowa State Over/Under

Iowa versus Iowa State, on Sept. 12, has an over/under of 41.5, with the over being -110 and the under -110.

Iowa vs Iowa State Moneyline

The Iowa vs Iowa State moneyline has Iowa as a -649 favorite, while Iowa State is a +460 underdog.

Iowa vs. Iowa State Points Insights

• The average implied total for the Hawkeyes last season was 27.5 points, 0.5 fewer points than their implied total of 28 points in Saturday's game.
• The average implied point total last season for the Cyclones (29.3) is 15.3 more points than the team's implied total in this matchup (14).

Iowa vs. Iowa State Game Info

• Game day: Saturday, September 12, 2026
• Game time: 7:30 p.m. ET
• TV channel: NBC/Peacock
• Location: Iowa City, Iowa
• Stadium: Kinnick Stadium

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