Iowa State vs West Virginia Prediction, Odds, Picks, Best Bets for Week 5 2026

On Saturday in college football, the Iowa State Cyclones are up against the West Virginia Mountaineers.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

Iowa State vs West Virginia Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Iowa State: (-152) | West Virginia: (+126)
• Spread: Iowa State: -2.5 (-122) | West Virginia: +2.5 (100)
• Total: 52.5 -- Over: (-118) | Under: (-104)

Iowa State vs West Virginia Betting Trends

• Iowa State has won twice against the spread this year.
• Iowa State has won once ATS (1-1) as a 2.5-point or higher favorite this season.
• Iowa State has had two games (out of four) go over the total this season.
• West Virginia owns two wins against the spread this season.
• West Virginia has covered every time (1-0) as a 2.5-point or greater underdog this year.
• Every West Virginia game has hit the over this year.

Iowa State vs West Virginia Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cyclones win (73.4%)

Iowa State vs West Virginia Point Spread

Iowa State is favored by 2.5 points (-122 to cover) in this matchup. West Virginia, the underdog, is +100.

Iowa State vs West Virginia Over/Under

Iowa State versus West Virginia on Oct. 3 has an over/under of 52.5 points, with the over -118 and the under -104.

Iowa State vs West Virginia Moneyline

The moneyline numbers for Iowa State vs. West Virginia reveal Iowa State as the favorite (-152) and West Virginia as the underdog (+126).

Iowa State vs. West Virginia Points Insights

Iowa State vs. West Virginia Game Info

• Game day: Saturday, October 3, 2026
• Game time: 12 p.m. ET
• TV channel: TNT
• Location: Ames, Iowa
• Stadium: Jack Trice Stadium

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Check out even more in-depth Iowa State vs. West Virginia analysis on FanDuel Research.