A Sweet 16 matchup will feature the No. 2 seed Iowa State Cyclones (29-7) and the No. 3 seed Illinois Fighting Illini (28-8) playing on Thursday at TD Garden. The NCAA Tournament contest tips off at 10:09 PM ET.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Iowa State vs. Illinois Game Info and Odds

• Game Day: Thursday, March 28, 2024
• Game Time: 10:09 PM ET
• TV Channel: TBS/truTV
• Location: Boston, Massachusetts
• Arena: TD Garden

Iowa State vs. Illinois Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Illinois win (52.3%)

Read the betting insights and trends below before making a wager on Thursday's Iowa State-Illinois spread (Iowa State -1.5) or over/under (147.5 points).

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Iowa State vs. Illinois: ATS Betting Stats and Trends

• Iowa State has won 26 games against the spread this season, while failing to cover 10 times.
• Illinois is 22-14-0 ATS this year.
• As a 1.5-point underdog or more in 2023-24, Illinois is 4-2 against the spread compared to the 19-8 ATS record Iowa State racks up as a 1.5-point favorite.
• The Cyclones have done a better job covering the spread at home (14-4-0) than they have in road tilts (7-3-0).
• The Fighting Illini's winning percentage against the spread at home is .500 (9-9-0). Away, it is .636 (7-4-0).

Iowa State vs. Illinois: Moneyline Betting Stats

• Iowa State has come away with 22 wins in the 25 contests it has been listed as the moneyline favorite in this season.
• This season, the Cyclones have come away with a win 22 times in 25 chances when named as a favorite of at least -113 or better on the moneyline.
• Illinois has put together a 3-3 record in games it was listed as the moneyline underdog (winning 50% of those games).
• The Fighting Illini have a 3-3 record (winning 50% of their games) when playing as a moneyline underdog of -106 or longer.
• Iowa State has an implied victory probability of 53.1% according to the moneyline set by sportsbooks for this matchup.

Iowa State vs. Illinois Head-to-Head Comparison

• Iowa State is outscoring opponents by 14.2 points per game with a +513 scoring differential overall. It puts up 75.5 points per game (113th in college basketball) and allows 61.3 per outing (fourth in college basketball).
• Keshon Gilbert ranks 438th in the country with a team-high 13.7 points per game.
• Illinois' +403 scoring differential (outscoring opponents by 11.2 points per game) is a result of putting up 84.6 points per game (eighth in college basketball) while allowing 73.4 per contest (230th in college basketball).
• Terrence Shannon Jr.'s team-leading 23.3 points per game rank him third in the nation.
• The Cyclones record 33.8 rebounds per game (268th in college basketball) compared to the 32.9 of their opponents.
• Tre King averages 5.3 rebounds per game (ranking 512th in college basketball) to lead the Cyclones.
• The Fighting Illini win the rebound battle by 8.3 boards on average. They record 41 rebounds per game, eighth in college basketball, while their opponents pull down 32.7.
• Quincy Guerrier's 6.2 rebounds per game lead the Fighting Illini and rank 306th in the nation.
• Iowa State ranks 71st in college basketball by averaging 99.4 points per 100 possessions on offense, and defensively is second in college basketball, allowing 80.7 points per 100 possessions.
• The Fighting Illini rank 12th in college basketball averaging 105.4 points per 100 possessions on offense, and defensively are 130th, allowing 91.5 points per 100 possessions.

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