Illinois vs Michigan State Prediction, Odds, Picks, Best Bets for Week 6 2026

The Illinois Fighting Illini will face the Michigan State Spartans in college football action on Saturday.

We've got you covered, in terms of the most important information about NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Illinois vs Michigan State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Illinois: (-132) | Michigan State: (+110)
• Spread: Illinois: -2.5 (-112) | Michigan State: +2.5 (-108)
• Total: 48.5 -- Over: (-112) | Under: (-108)

Illinois vs Michigan State Betting Trends

• Illinois has two wins against the spread this year.
• Illinois owns one win ATS (1-3) as a 2.5-point favorite or greater this season.
• There have been four Illinois games (of five) that hit the over this year.
• Michigan State has posted two wins against the spread this season.
• Michigan State has one win ATS (1-2) as a 2.5-point underdog or more this year.
• Michigan State has had one game (of five) go over the total this year.

Illinois vs Michigan State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Illini win (59.9%)

Illinois vs Michigan State Point Spread

Illinois is favored by 2.5 points against Michigan State. Illinois is -112 to cover the spread, while Michigan State is -108.

Illinois vs Michigan State Over/Under

An over/under of 48.5 has been set for Illinois-Michigan State on Oct. 10, with the over being -112 and the under -108.

Illinois vs Michigan State Moneyline

Illinois is a -132 favorite on the moneyline, while Michigan State is a +110 underdog.

Illinois vs. Michigan State Points Insights

Illinois vs. Michigan State Game Info

• Game day: Saturday, October 10, 2026
• Game time: 3:30 p.m. ET
• TV channel: Fox Sports 1
• Location: East Lansing, Michigan
• Stadium: Spartan Stadium

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Check out even more in-depth Illinois vs. Michigan State analysis on FanDuel Research.