Guardians vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for ALDS Game 4 on Oct. 8

Odds updated as of 8:12 a.m.

On Thursday in the MLB, the Cleveland Guardians are playing the Chicago White Sox in Game 4 of the ALDS.

We've got you covered, in terms of the vital info about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Guardians vs White Sox Game Info

• Cleveland Guardians (85-77) vs. Chicago White Sox (84-78)
• Date: Thursday, October 8, 2026
• Time: 8 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: truTV, TBS, and HBO Max

Guardians vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-118) | CHW: (+100)
• Spread: CLE: -1.5 (+150) | CHW: +1.5 (-182)
• Total: 7.5 -- Over: (+100) | Under: (-122)

Guardians vs White Sox Probable Starting Pitchers

Probable Pitchers: Parker Messick (Guardians) - 12-9, 2.56 ERA vs Hagen Smith (White Sox) - 3-3, 1.29 ERA

The probable starters are Parker Messick (12-9, 2.56 ERA) for the Guardians and Hagen Smith (3-3, 1.29 ERA) for the White Sox. Messick and his team are 16-17-0 ATS this season when he starts. When Messick starts a game and his team is the favorite on the moneyline, they have a record of 12-13. The White Sox have gone 2-1-0 ATS in Smith's three starts with a set spread. The White Sox were the moneyline underdog for two Smith starts this season -- they won both.

Guardians vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: White Sox win (50.4%)

Guardians vs White Sox Moneyline

• The moneyline numbers for Guardians vs. White Sox reveal Cleveland as the favorite (-118) and Chicago as the underdog (+100) despite being the home team.

Guardians vs White Sox Spread

• The Guardians are favored by 1.5 runs on the road versus the White Sox. The Guardians are +150 to cover the spread, while the White Sox are -182.

Guardians vs White Sox Over/Under

• The over/under for the Guardians versus White Sox game on Oct. 8 has been set at 7.5, with +100 odds on the over and -122 odds on the under.

Bet on Cleveland Guardians vs. Chicago White Sox on FanDuel today!

Guardians vs White Sox Betting Trends

• The Guardians have been favorites in 92 games this season and have come away with the win 48 times (52.2%) in those contests.
• This year Cleveland has won 41 of 76 games when listed as at least -118 on the moneyline.
• The Guardians and their opponents have gone over in 76 of their 155 games with a total set by sportsbooks this season.
• The Guardians are 74-81-0 against the spread in their 155 games that had a posted line this season.
• The White Sox have won 49.5% of the games this season they were the underdog on the moneyline (54-55).
• In games it has played as a moneyline underdog with odds of +100 or longer, Chicago has a 46-47 record (winning 49.5% of its games).
• The White Sox have combined with opponents to hit the over on the total 93 times this season for a 93-70-1 record against the over/under.
• The White Sox have gone 94-70-0 against the spread this season.

Guardians Player Leaders

• Chase DeLauter leads Cleveland with 142 hits, batting .287 this season with 49 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .457.
• Among all qualifying batters in baseball, he ranks 16th in batting average, 24th in on-base percentage, and 43rd in slugging.
• DeLauter will look for his third straight game with a hit in this contest. During his last five outings he is hitting .250 with a double, a home run, four walks and three RBIs.
• Steven Kwan leads the Guardians with an OPS of .731. He has a slash line of .282/.382/.349 this season.
• He is 21st in batting average, seventh in on-base percentage and 131st in slugging among qualifying batters.
• Kwan brings a two-game streak with at least one hit into this matchup. In his last five games he is hitting .250 with a triple, four walks and two RBIs.
• Jose Ramirez is batting .235 with a .368 slugging percentage and 53 RBI this year.
• Brayan Rocchio is batting .253 with a .313 OBP and 73 RBI for Cleveland this season.

White Sox Player Leaders

• Miguel Vargas has 31 doubles, a triple, 33 home runs and 101 walks while hitting .250. He's slugging .474 with an on-base percentage of .363.
• Including all qualifying hitters in the majors, his batting average puts him 79th, his on-base percentage is 24th, and he is 30th in slugging.
• Vargas enters this game on a three-game hitting streak. During his last five outings he is batting .176 with six walks.
• Chase Meidroth's .415 slugging percentage paces his team. He has a batting average of .276 with an on-base percentage of .350.
• His batting average ranks 33rd among all qualified players, his on-base percentage ranks 45th, and he is 80th in slugging.
• Sam Antonacci a has .370 on-base percentage to pace the White Sox.
• Munetaka Murakami paces his team with 94 hits.

Guardians vs White Sox Head to Head

• 10/7/2026: 9-3 CLE (Favorite: White Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -128, Underdog Moneyline: +112)
• 10/5/2026: 4-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -152, Underdog Moneyline: +136)
• 10/3/2026: 3-0 CHW (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -144, Underdog Moneyline: +128)
• 9/16/2026: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/15/2026: 7-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/14/2026: 7-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/9/2026: 5-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/8/2026: 6-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/7/2026: 8-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +126)
• 7/4/2026: 3-1 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)

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