Guardians vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for ALDS Game 2 on Oct. 5

Odds updated as of 4:11 a.m.

The Monday schedule in the MLB includes a matchup between the Cleveland Guardians and the Chicago White Sox for Game 2 of the ALDS.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this game.

Guardians vs White Sox Game Info

• Cleveland Guardians (85-77) vs. Chicago White Sox (84-78)
• Date: Monday, October 5, 2026
• Time: 5 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: truTV, TBS, and HBO Max

Guardians vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-154) | CHW: (+130)
• Spread: CLE: -1.5 (+152) | CHW: +1.5 (-184)
• Total: 6.5 -- Over: (-118) | Under: (-104)

Guardians vs White Sox Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 14-8, 3.76 ERA vs Anthony Kay (White Sox) - 10-9, 4.50 ERA

The Guardians will give the nod to Gavin Williams (14-8, 3.76 ERA) versus the White Sox and Anthony Kay (10-9, 4.50 ERA). Williams' team is 14-15-0 against the spread this season in his starts. Williams' team has a record of 14-10 this season when he starts and they are the favorite on the moneyline. When Kay starts, the White Sox are 20-10-0 against the spread. The White Sox are 13-10 in Kay's 23 starts this season that they were the moneyline underdog.

Guardians vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (59.6%)

Guardians vs White Sox Moneyline

• The Guardians vs White Sox moneyline has Cleveland as a -154 favorite, while Chicago is a +130 underdog on the road.

Guardians vs White Sox Spread

• The Guardians are 1.5-run home favorites on the runline against the White Sox. The Guardians are +152 to cover, and the White Sox are -184.

Guardians vs White Sox Over/Under

• The over/under for the Guardians versus White Sox game on Oct. 5 has been set at 6.5, with -118 odds on the over and -104 odds on the under.

Bet on Cleveland Guardians vs. Chicago White Sox on FanDuel today!

Guardians vs White Sox Betting Trends

• The Guardians have been victorious in 48, or 52.7%, of the 91 contests they have been chosen as favorites in this season.
• This year Cleveland has won 19 of 28 games when listed as at least -154 on the moneyline.
• The Guardians and their opponents have gone over in 74 of their 153 games with a total set by sportsbooks this season.
• The Guardians have an against the spread record of 73-80-0 in 153 games with a line this season.
• The White Sox have won 53 of the 108 games they were the underdog on the moneyline this season (49.1%).
• When it has played as a moneyline underdog with odds of +130 or longer, Chicago has gone 13-19 (40.6%).
• In the 162 games oddsmakers have set an over/under for the White Sox, they have combined with opponents to go over the total 91 times (91-70-1).
• The White Sox have a 93-69-0 record ATS this season (covering 57.4% of the time).

Guardians Player Leaders

• Chase DeLauter leads Cleveland in total hits (142) this season while batting .287 with 49 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .457.
• He ranks 16th in batting average, 24th in on-base percentage, and 43rd in slugging among all qualified batters in the majors.
• Steven Kwan has a slash line of .282/.382/.349 this season and a team-best OPS of .731.
• Among qualified batters, he ranks 21st in batting average, seventh in on-base percentage and 131st in slugging percentage.
• Jose Ramirez has collected 111 base hits, an OBP of .320 and a slugging percentage of .368 this season.
• Brayan Rocchio is batting .253 with a .313 OBP and 73 RBI for Cleveland this season.

White Sox Player Leaders

• Miguel Vargas has 31 doubles, a triple, 33 home runs and 101 walks while hitting .250. He's slugging .474 with an on-base percentage of .363.
• Including all qualifying hitters in the majors, he is 79th in batting average, 24th in on-base percentage and 30th in slugging percentage.
• Chase Meidroth is slugging .415 to lead his team. He has a batting average of .276 with an on-base percentage of .350.
• Including all qualified hitters, his batting average places him 33rd, his on-base percentage is 45th, and he is 80th in slugging.
• Sam Antonacci a has .370 on-base percentage to lead the White Sox.
• Munetaka Murakami's 94 hits pace his team.

Guardians vs White Sox Head to Head

• 10/3/2026: 3-0 CHW (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -144, Underdog Moneyline: +128)
• 9/16/2026: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/15/2026: 7-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/14/2026: 7-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/9/2026: 5-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/8/2026: 6-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/7/2026: 8-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +126)
• 7/4/2026: 3-1 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/3/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/2/2026: 6-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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