Guardians vs Tigers Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 5

Odds updated as of 5:14 p.m.

On Saturday in MLB, the Cleveland Guardians are up against the Detroit Tigers.

We've got you covered, in terms of the most important information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Tigers Game Info

• Cleveland Guardians (72-70) vs. Detroit Tigers (64-77)
• Date: Saturday, September 5, 2026
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and DSN

Guardians vs Tigers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-158) | DET: (+134)
• Spread: CLE: -1.5 (+140) | DET: +1.5 (-170)
• Total: 7 -- Over: (-102) | Under: (-120)

Guardians vs Tigers Probable Starting Pitchers

Probable Pitchers: Parker Messick (Guardians) - 11-8, 2.46 ERA vs Framber Valdez (Tigers) - 8-10, 4.36 ERA

The Guardians will give the nod to Parker Messick (11-8) against the Tigers and Framber Valdez (8-10). Messick and his team have a record of 14-13-0 against the spread when he starts. When Messick starts a game and his team is the favorite on the moneyline, they have a record of 10-11. When Valdez starts, the Tigers are 11-14-0 against the spread. The Tigers have been the moneyline underdog in 11 of Valdez's starts this season, and they went 6-5 in those games.

Guardians vs Tigers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (52.7%)

Guardians vs Tigers Moneyline

• Cleveland is the favorite, -158 on the moneyline, while Detroit is a +134 underdog on the road.

Guardians vs Tigers Spread

• The Tigers are +1.5 on the run line against the Guardians. The Tigers are -170 to cover, and the Guardians are +140.

Guardians vs Tigers Over/Under

• A combined run total of 7 has been set for Guardians-Tigers on Sept. 5, with the over at -102 and the under at -120.

Bet on Cleveland Guardians vs. Detroit Tigers on FanDuel today!

Guardians vs Tigers Betting Trends

• The Guardians have been victorious in 41, or 51.2%, of the 80 contests they have been chosen as favorites in this season.
• Cleveland has a record of 11-6 in contests when oddsmakers favor them by -158 or more on the moneyline.
• The Guardians' games have gone over the total in 65 of their 134 opportunities.
• The Guardians are 64-70-0 against the spread in their 134 games that had a posted line this season.
• The Tigers have a 25-33 record in games they were listed as the moneyline underdog (winning 43.1% of those games).
• Detroit has a record of 2-6 in games it has played as a moneyline underdog with odds of +134 or longer (25%).
• The Tigers have had an over/under set by oddsmakers 136 times, and have combined with opponents to go over the total in 59 of those games (59-74-3).
• The Tigers have covered 50.7% of their games this season, going 69-67-0 against the spread.

Guardians Player Leaders

• Chase DeLauter has 131 hits to go with a slugging percentage of .458, both of which lead Cleveland hitters this season. He has a .294 batting average and an on-base percentage of .365.
• Among all qualifying batters in baseball, his batting average ranks 10th, his on-base percentage ranks 19th, and he is 41st in slugging.
• Jose Ramirez is hitting .239 with 24 doubles, 11 home runs and 56 walks, while slugging .382 with an on-base percentage of .333.
• He ranks 100th in batting average, 66th in on-base percentage and 108th in slugging in MLB.
• Steven Kwan leads Cleveland in OBP (.374) this season, fueled by 127 hits.
• Brayan Rocchio is batting .247 with a .308 OBP and 59 RBI for Cleveland this season.
• Rocchio has hit safely in two games in a row. In his last five games he is hitting .235 with a double, two home runs, a walk and five RBIs.

Tigers Player Leaders

• Kevin McGonigle has put up an on-base percentage of .372 and a slugging percentage of .410. Both lead the Tigers. He's batting .272.
• Including all the qualified hitters in the big leagues, he is 38th in batting average, 14th in on-base percentage and 83rd in slugging percentage.
• Dillon Dingler leads his team with 123 hits. He has a batting average of .249 while slugging .466 with an on-base percentage of .313.
• He is currently 82nd in batting average, 101st in on-base percentage and 34th in slugging percentage among all qualifying hitters.
• Riley Greene is batting .267 with 26 doubles, a triple, 16 home runs and 62 walks.
• Spencer Torkelson is hitting .223 with 24 doubles, 22 home runs and 58 walks.

Guardians vs Tigers Head to Head

• 8/13/2026: 3-0 DET (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: +100)
• 8/12/2026: 6-4 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +114)
• 8/11/2026: 6-4 DET (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +124)
• 6/13/2026: 3-1 CLE (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/12/2026: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/21/2026: 3-1 CLE (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/20/2026: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/19/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 10/2/2025: 6-3 DET (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 10/1/2025: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -130, Underdog Moneyline: +110)

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