Guardians vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 20

Odds updated as of 12:12 p.m.

Thursday's slate in the MLB includes a matchup between the Cleveland Guardians and the San Francisco Giants.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Giants Game Info

• Cleveland Guardians (61-66) vs. San Francisco Giants (52-74)
• Date: Thursday, August 20, 2026
• Time: 1:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and NBCS-BA

Guardians vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-205) | SF: (+190)
• Spread: CLE: -1.5 (+106) | SF: +1.5 (-128)
• Total: 7 -- Over: (-110) | Under: (-110)

Guardians vs Giants Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 11-7, 3.74 ERA vs Landen Roupp (Giants) - 7-12, 4.31 ERA

The Guardians will give the nod to Gavin Williams (11-7) versus the Giants and Landen Roupp (7-12). When Williams starts, his team is 11-13-0 against the spread this season. Williams' team has a record of 10-9 this season when he starts and they are the favorite on the moneyline. The Giants have a 7-17-0 record against the spread in Roupp's starts. The Giants are 6-10 in Roupp's 16 starts this season that they were the moneyline underdog.

Guardians vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (53.3%)

Guardians vs Giants Moneyline

• The Guardians vs Giants moneyline has Cleveland as a -205 favorite, while San Francisco is a +190 underdog on the road.

Guardians vs Giants Spread

• The Giants are at +1.5 on the runline against the Guardians. The Giants are -128 to cover the spread, and the Guardians are +106.

Guardians vs Giants Over/Under

• An over/under of 7 has been set for Guardians-Giants on Aug. 20, with the over being -110 and the under -110.

Bet on Cleveland Guardians vs. San Francisco Giants on FanDuel today!

Guardians vs Giants Betting Trends

• The Guardians have been chosen as favorites in 69 games this year and have walked away with the win 32 times (46.4%) in those games.
• Cleveland has played as a favorite of -205 or more just one time this year and came away with a loss in that game.
• The Guardians and their opponents have gone over in 59 of their 121 games with a total set by sportsbooks this season.
• The Guardians are 57-64-0 against the spread in their 121 games that had a posted line this season.
• The Giants have won 28 of the 79 games they were listed as the moneyline underdog this season (35.4%).
• San Francisco has a record of 2-2 when it has played as a moneyline underdog with odds of +190 or longer (50%).
• The Giants have played in 123 games with an over/under set, and have combined with their opponents to go over the total 57 times (57-57-9).
• The Giants have covered 45.5% of their games this season, going 56-67-0 ATS.

Guardians Player Leaders

• Chase DeLauter leads Cleveland with 115 hits and a team-best slugging percentage of .442. He's batting .285 with an on-base percentage of .358.
• He ranks 18th in batting average, 36th in on-base percentage, and 54th in slugging among qualified batters in MLB.
• Jose Ramirez is hitting .238 with 20 doubles, 10 home runs and 54 walks, while slugging .384 with an on-base percentage of .341.
• Among qualified hitters, his batting average ranks him 107th, his on-base percentage 57th, and his slugging percentage 113th.
• Steven Kwan has 107 hits this season and a team-best OBP of .368.
• Brayan Rocchio is batting .251 with a .314 OBP and 51 RBI for Cleveland this season.

Giants Player Leaders

• Jung Hoo Lee has a team-high OBP (.329) and slugging percentage (.435). He's batting .294.
• Including all qualified hitters in the majors, he ranks 10th in batting average, 78th in on-base percentage and 61st in slugging percentage.
• Lee heads into this matchup on a three-game hitting streak. During his last five outings he is hitting .238 with a double and a walk.
• Rafael Devers is batting .244 with 31 doubles, a triple, 25 home runs and 52 walks. He's slugging .471 with an on-base percentage of .317.
• He ranks 90th in batting average, 97th in on-base percentage and 34th in slugging percentage in MLB.
• Willy Adames is hitting .229 with 25 doubles, a triple, 19 home runs and 36 walks.
• Bryce Eldridge has 15 doubles, 14 home runs and 42 walks while hitting .247.

Guardians vs Giants Head to Head

• 8/19/2026: 1-0 SF (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -215, Underdog Moneyline: +198)
• 8/18/2026: 8-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -190, Underdog Moneyline: +176)
• 6/19/2025: 2-1 SF (Favorite: Giants, Spread: -1.5, Total: 7, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 6/18/2025: 4-2 CLE (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/17/2025: 3-2 CLE (Favorite: Giants, Spread: -1.5, Total: 7, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 7/7/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/6/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/5/2024: 4-2 SF (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/13/2023: 6-5 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/12/2023: 3-1 CLE (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -180, Underdog Moneyline: +152)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!