Guardians vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 20

Odds updated as of 1:11 p.m.

The Cleveland Guardians will take on the Athletics in MLB action on Sunday.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Athletics Game Info

• Cleveland Guardians (80-75) vs. Athletics (61-94)
• Date: Sunday, September 20, 2026
• Time: 1:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and NBCS-CA

Guardians vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-245) | OAK: (+200)
• Spread: CLE: -1.5 (-105) | OAK: +1.5 (-114)
• Total: 6.5 -- Over: (-142) | Under: (+116)

Guardians vs Athletics Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 13-8, 3.78 ERA vs Jack Perkins (Athletics) - 3-11, 6.14 ERA

The probable starters are Gavin Williams (13-8) for the Guardians and Jack Perkins (3-11) for the Athletics. When Williams starts, his team is 14-15-0 against the spread this season. When Williams starts a game and his team is the favorite on the moneyline, they have a record of 14-10. The Athletics have gone 4-11-0 ATS in Perkins' 15 starts with a set spread. The Athletics are 1-9 in Perkins' 10 starts this season that they were the underdog on the moneyline.

Guardians vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (56.6%)

Guardians vs Athletics Moneyline

• The Guardians vs Athletics moneyline has the Guardians as a -245 favorite, while the Athletics are a +200 underdog on the road.

Guardians vs Athletics Spread

• The Guardians are 1.5-run favorites on the runline against the Athletics. The Guardians are -105 to cover, while the Athletics are -114 to cover.

Guardians vs Athletics Over/Under

• The over/under for Guardians-Athletics on Sept. 20 is 6.5. The over is -142, and the under is +116.

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Guardians vs Athletics Betting Trends

• The Guardians have been favorites in 89 games this season and have come away with the win 47 times (52.8%) in those contests.
• The Guardians have yet to enter a game this year with shorter moneyline odds than -245.
• The Guardians and their opponents have hit the over in 73 of their 147 games with a total this season.
• In 147 games with a line this season, the Guardians have a mark of 70-77-0 against the spread.
• The Athletics have put together a 45-73 record in games they were the underdog on the moneyline (winning 38.1% of those games).
• The Athletics have a record of 3-3 when playing as a moneyline underdog with odds of +200 or longer (50%).
• The Athletics have played in 155 games with an over/under set, and have combined with their opponents to go over the total 80 times (80-73-2).
• The Athletics have gone 73-82-0 against the spread this season.

Guardians Player Leaders

• Chase DeLauter has 137 hits, which is best among Cleveland hitters this season, while batting .290 with 46 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .458.
• Among qualified batters in baseball, he is 10th in batting average, 24th in on-base percentage, and 38th in slugging.
• DeLauter will look for his third straight game with a hit in this contest. In his last five games he is hitting .222 with a home run, four walks and three RBIs.
• Steven Kwan has a slash line of .277/.376/.342 this season and a team-best OPS of .718.
• Among qualified hitters, his batting average ranks him 27th, his on-base percentage 12th, and his slugging percentage 129th.
• Jose Ramirez has collected 105 base hits, an OBP of .322 and a slugging percentage of .373 this season.
• Ramirez heads into this game with three games in a row with at least one hit. In his last five games he is hitting .333 with two doubles, a home run, a walk and three RBIs.
• Brayan Rocchio has been key for Cleveland with 129 hits, an OBP of .312 plus a slugging percentage of .381.
• Rocchio enters this matchup on a two-game hitting streak. In his last five games he is hitting .400 with three doubles, three walks and five RBIs.

Athletics Player Leaders

• Jeff McNeil has a slugging percentage of .365, a team-high for the Athletics. He's batting .265 with an on-base percentage of .312.
• Including all qualifying hitters, he ranks 52nd in batting average, while his on-base percentage ranks 98th and he is 117th in slugging.
• Shea Langeliers has 19 doubles, 23 home runs and 35 walks while batting .265. He's slugging .487 with an on-base percentage of .332.
• Lawrence Butler has accumulated an on-base percentage of .321 and has 102 hits, both team-best numbers for the Athletics.
• Zack Gelof is batting .249 with 15 doubles, two triples, 19 home runs and 29 walks.

Guardians vs Athletics Head to Head

• 9/19/2026: 12-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 9/18/2026: 5-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 5/3/2026: 7-1 OAK (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/2/2026: 14-6 CLE (Favorite: Athletics, Spread: -1.5, Total: 10.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 5/1/2026: 8-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/20/2025: 8-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/19/2025: 8-2 OAK (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/18/2025: 8-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/22/2025: 3-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/21/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +114)

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