Giants vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 7

Odds updated as of 8:12 p.m.

Monday's slate in the MLB includes a matchup between the San Francisco Giants and the St. Louis Cardinals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this game.

Giants vs Cardinals Game Info

• San Francisco Giants (59-85) vs. St. Louis Cardinals (72-72)
• Date: Monday, September 7, 2026
• Time: 8:10 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBC/Peacock

Giants vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-134) | STL: (+114)
• Spread: SF: -1.5 (+158) | STL: +1.5 (-192)
• Total: 7.5 -- Over: (-124) | Under: (+102)

Giants vs Cardinals Probable Starting Pitchers

Probable Pitchers: Logan Webb (Giants) - 8-8, 4.21 ERA vs Michael McGreevy (Cardinals) - 6-9, 3.97 ERA

The probable pitchers are Logan Webb (8-8) for the Giants and Michael McGreevy (6-9) for the Cardinals. When Webb starts, his team is 12-13-0 against the spread this season. Webb's team has won 46.7% of his starts when they are favored on the moneyline (7-8). The Cardinals have a 15-12-0 record against the spread in McGreevy's starts. The Cardinals are 10-9 in McGreevy's 19 starts this season that they were the moneyline underdog.

Giants vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (52.5%)

Giants vs Cardinals Moneyline

• St. Louis is the underdog, +114 on the moneyline, while San Francisco is a -134 favorite at home.

Giants vs Cardinals Spread

• The Giants are hosting the Cardinals and are favored by 1.5 runs on the spread. The Giants are +158 to cover the runline, with the Cardinals being -192.

Giants vs Cardinals Over/Under

• The over/under for Giants-Cardinals on Sept. 7 is 7.5. The over is -124, and the under is +102.

Bet on San Francisco Giants vs. St. Louis Cardinals on FanDuel today!

Giants vs Cardinals Betting Trends

• The Giants have been chosen as favorites in 44 games this year and have walked away with the win 20 times (45.5%) in those games.
• This year San Francisco has won eight of 17 games when listed as at least -134 on the moneyline.
• The Giants' games have gone over the total in 67 of their 141 opportunities.
• The Giants have posted a record of 67-74-0 against the spread this season.
• The Cardinals have won 46.8% of the games this season they were the moneyline underdog (44-50).
• St. Louis has a 27-28 record (winning 49.1% of its games) when it has played as a moneyline underdog of +114 or longer.
• The Cardinals have played in 140 games with a set over/under, and have combined with opponents to go over the total 63 times (63-70-7).
• The Cardinals have gone 76-64-0 against the spread this season.

Giants Player Leaders

• Rafael Devers leads San Francisco with 140 hits and an OBP of .338, plus a team-best slugging percentage of .517. He's batting .258.
• Among qualifying hitters in MLB, his batting average ranks 65th, his on-base percentage ranks 54th, and he is 10th in slugging.
• Devers has recorded a base hit in three games in a row. During his last five outings he is batting .421 with two doubles, four home runs, three walks and nine RBIs.
• Jung Hoo Lee is hitting .280 with 28 doubles, four triples, nine home runs and 26 walks, while slugging .407 with an on-base percentage of .323.
• He is 23rd in batting average, 86th in on-base percentage and 86th in slugging among qualified batters.
• Bryce Eldridge is batting .262 with a .447 slugging percentage and 45 RBI this year.
• Eldridge brings a three-game hitting streak into this game. In his last five games he is batting .250 with three doubles, five walks and two RBIs.
• Drew Gilbert has eight home runs, 36 RBI and a batting average of .232 this season.

Cardinals Player Leaders

• Alec Burleson is batting .283 with 34 doubles, a triple, 21 home runs and 48 walks. He's slugging .464 with an on-base percentage of .345.
• Including all qualified hitters in MLB, his batting average puts him 16th, his on-base percentage is 47th, and he is 36th in slugging.
• Burleson enters this game on a three-game hitting streak. In his last five games he is hitting .238 with a double and three RBIs.
• Jordan Walker's 156 hits and .495 slugging percentage both pace his team. He has a batting average of .284 with an on-base percentage of .339.
• He is currently 14th in batting average, 52nd in on-base percentage and 15th in slugging percentage among all qualifying hitters.
• Ivan Herrera a has .361 on-base percentage to lead the Cardinals.
• Nathan Church has 11 doubles, two triples, 10 home runs and 21 walks while hitting .243.

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