Florida vs South Carolina Prediction, Odds, Picks, Best Bets for Week 6 2026

On Saturday in college football, the Florida Gators are up against the South Carolina Gamecocks.

Get the latest NCAA football odds ahead of this game on FanDuel Sportsbook.

Florida vs South Carolina Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Florida: (-450) | South Carolina: (+340)
• Spread: Florida: -11.5 (-110) | South Carolina: +11.5 (-110)
• Total: 60.5 -- Over: (-105) | Under: (-115)

Florida vs South Carolina Betting Trends

• Against the spread, Florida is 3-2-0 this year.
• Florida owns one win ATS (1-1) as an 11.5-point favorite or greater this season.
• This year, four of Florida's five games have hit the over.
• South Carolina has posted one win against the spread this year.
• South Carolina has no wins ATS (0-1) as an 11.5-point underdog or greater this year.
• South Carolina has seen four of its five games hit the over.

Florida vs South Carolina Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Gators win (73%)

Florida vs South Carolina Point Spread

Florida is a 11.5-point favorite against South Carolina. Florida is -110 to cover the spread, and South Carolina is -110.

Florida vs South Carolina Over/Under

Florida versus South Carolina, on Oct. 10, has an over/under of 60.5, with the over being -105 and the under -115.

Florida vs South Carolina Moneyline

Looking at the moneyline for Florida-South Carolina, Florida is the favorite at -450, and South Carolina is +340.

Florida vs. South Carolina Points Insights

Florida vs. South Carolina Game Info

• Game day: Saturday, October 10, 2026
• Game time: 12:45 p.m. ET
• TV channel: SEC Network
• Location: Gainesville, Florida
• Stadium: Ben Hill Griffin Stadium

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Check out even more in-depth Florida vs. South Carolina analysis on FanDuel Research.