Duke vs UConn Prediction, Odds, Picks, Best Bets for Week 11 2025

NCAA football action on Saturday includes the Duke Blue Devils facing the UConn Huskies.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Duke vs UConn Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Duke: (-310) | UConn: (+250)
• Spread: Duke: -7.5 (-115) | UConn: +7.5 (-105)
• Total: 64.5 -- Over: (-105) | Under: (-115)

Duke vs UConn Betting Trends

• Against the spread, Duke is 4-4-0 this season.
• Duke is winless ATS (0-1) as a 7.5-point favorite or greater this year.
• This season, six of Duke's eight games have go over the point total.
• UConn is 5-4-0 against the spread this season.
• UConn has covered every time (1-0) as a 7.5-point or greater underdog this season.
• UConn has played nine games this year, and six of them have hit the over.

Duke vs UConn Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Blue Devils win (62.6%)

Duke vs UConn Point Spread

Duke is favored by 7.5 points (-115 to cover) in this matchup. UConn, the underdog, is -105.

Duke vs UConn Over/Under

Duke versus UConn, on Nov. 8, has an over/under of 64.5, with the over being -105 and the under -115.

Duke vs UConn Moneyline

Looking at the moneyline for UConn-Duke, UConn is the underdog at +250, and Duke is -310.

Duke vs. UConn Points Insights

Duke vs. UConn Game Info

• Game day: Saturday, November 8, 2025
• Game time: 3:30 p.m. ET
• TV channel: CBS Sports Network
• Location: East Hartford, Connecticut
• Stadium: Pratt and Whitney Stadium at Rentschler Field

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Check out even more in-depth Duke vs. UConn analysis on FanDuel Research.