Duke vs Tulane Prediction, Odds, Picks, Best Bets for Week 1 2026

On Saturday in college football, the Duke Blue Devils are playing the Tulane Green Wave.

We've got you covered, in terms of the vital info about NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Duke vs Tulane Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Duke: (-319) | Tulane: (+255)
• Spread: Duke: -7.5 (-110) | Tulane: +7.5 (-110)
• Total: 50.5 -- Over: (-114) | Under: (-106)

Duke vs Tulane Betting Trends

• Duke's record against the spread last season was 6-7-1.
• Duke didn't have a win ATS (0-2) as favorites of 7.5 points or greater last season.
• Duke had 10 of its 14 games hit the over last season.
• Against the spread, Tulane was 7-7-0 last year.
• Tulane had no wins ATS (0-2) as underdogs of 7.5 points or more last season.
• Last year, four of Tulane's 14 games hit the over.

Duke vs Tulane Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Blue Devils win (60.3%)

Duke vs Tulane Point Spread

Duke is favored by 7.5 points over Tulane. Duke is -110 to cover the spread, with Tulane being -110.

Duke vs Tulane Over/Under

The over/under for the Duke versus Tulane matchup on Sept. 5 has been set at 50.5, with -114 odds on the over and -106 odds on the under.

Duke vs Tulane Moneyline

Duke is a -319 favorite on the moneyline, while Tulane is a +255 underdog.

Duke vs. Tulane Points Insights

• The Blue Devils had an average implied point total of 30.9 last season, which is 1.9 points higher than their implied total in Saturday's game (29).
• The 32.5-point average implied total last season for the Green Wave is 10.5 more points than the team's 22-point implied total in this matchup.

Duke vs. Tulane Game Info

• Game day: Saturday, September 5, 2026
• Game time: 3:30 p.m. ET
• TV channel: ACC Network
• Location: Wilmington, North Carolina
• Stadium: Brooks Field at Wallace Wade Stadium

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Check out even more in-depth Duke vs. Tulane analysis on FanDuel Research.