Duke vs North Carolina Prediction, Odds, Picks, Best Bets for Week 13 2025

NCAA football action on Saturday includes the Duke Blue Devils playing the North Carolina Tar Heels.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Duke vs North Carolina Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Duke: (-245) | North Carolina: (+200)
• Spread: Duke: -6.5 (-115) | North Carolina: +6.5 (-105)
• Total: 50.5 -- Over: (-105) | Under: (-115)

Duke vs North Carolina Betting Trends

• Duke has four wins in 10 games against the spread this year.
• Duke has yet to win ATS (0-2) when playing as at least 6.5-point favorites this season.
• Out of 10 Duke games so far this season, seven have hit the over.
• North Carolina's record against the spread in 2025 is 5-5-0.
• As a 6.5-point underdog or more, North Carolina has two wins ATS (2-2).
• Of 10 North Carolina games so far this year, three have hit the over.

Duke vs North Carolina Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Blue Devils win (74.4%)

Duke vs North Carolina Point Spread

Duke is favored by 6.5 points against North Carolina. Duke is -115 to cover the spread, while North Carolina is -105.

Duke vs North Carolina Over/Under

A total of 50.5 points has been set for the Duke-North Carolina game on Nov. 22, with the over available at -105 and the under at -115.

Duke vs North Carolina Moneyline

Duke is the favorite, -245 on the moneyline, while North Carolina is a +200 underdog.

Duke vs. North Carolina Points Insights

Duke vs. North Carolina Game Info

• Game day: Saturday, November 22, 2025
• Game time: 3:30 p.m. ET
• TV channel: ACC Network
• Location: Chapel Hill, North Carolina
• Stadium: Kenan Stadium

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