Diamondbacks vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 22

Odds updated as of 7:12 p.m.

On Saturday in MLB, the Arizona Diamondbacks are up against the Cincinnati Reds.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Diamondbacks vs Reds Game Info

• Arizona Diamondbacks (68-61) vs. Cincinnati Reds (61-68)
• Date: Saturday, August 22, 2026
• Time: 8:10 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: Dbacks.TV and Reds.TV

Diamondbacks vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-126) | CIN: (+108)
• Spread: ARI: -1.5 (+160) | CIN: +1.5 (-194)
• Total: 8.5 -- Over: (-112) | Under: (-108)

Diamondbacks vs Reds Probable Starting Pitchers

Probable Pitchers: Mike Soroka (Diamondbacks) - 8-3, 2.93 ERA vs Rhett Lowder (Reds) - 4-8, 5.17 ERA

This contest's pitching matchup is set, as the Diamondbacks will send Mike Soroka (8-3) to the mound, while Rhett Lowder (4-8) will get the nod for the Reds. Soroka's team is 9-7-0 against the spread in his starts this season. Soroka's team has a record of 7-3 this season when he starts and they are the favorite on the moneyline. The Reds are 9-10-0 against the spread when Lowder starts. The Reds have an 8-8 record in Lowder's 16 starts this season when they were the moneyline underdog.

Diamondbacks vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (68.7%)

Diamondbacks vs Reds Moneyline

• The Diamondbacks vs Reds moneyline has Arizona as a -126 favorite, while Cincinnati is a +108 underdog on the road.

Diamondbacks vs Reds Spread

• The Diamondbacks are 1.5-run home favorites on the runline against the Reds. The Diamondbacks are +160 to cover, and the Reds are -194.

Diamondbacks vs Reds Over/Under

• The over/under for the Diamondbacks versus Reds game on Aug. 22 has been set at 8.5, with -112 odds on the over and -108 odds on the under.

Bet on Arizona Diamondbacks vs. Cincinnati Reds on FanDuel today!

Diamondbacks vs Reds Betting Trends

• The Diamondbacks have been chosen as favorites in 52 games this year and have walked away with the win 31 times (59.6%) in those games.
• Arizona has a record of 18-12 in contests when oddsmakers favor them by -126 or more on the moneyline.
• The Diamondbacks and their opponents have gone over the total this season in 56 of their 128 opportunities.
• The Diamondbacks have an against the spread mark of 69-59-0 in 128 games with a line this season.
• The Reds have won 39 of the 84 games they were the underdog on the moneyline this season (46.4%).
• Cincinnati is 23-30 (winning 43.4% of its games) when playing as a moneyline underdog of +108 or longer.
• The Reds have combined with opponents to hit the over on the total 67 times this season for a 67-57-2 record against the over/under.
• The Reds have put together a 66-60-0 record ATS this season.

Diamondbacks Player Leaders

• Corbin Carroll has 116 hits, which leads Arizona hitters this season, while batting .248 with 60 extra-base hits. He has an on-base percentage of .348 and a slugging percentage of .486.
• Among qualified hitters in baseball, he ranks 83rd in batting average, 49th in on-base percentage, and 24th in slugging.
• Carroll hopes to build on a two-game hitting streak in this matchup. During his last five outings he is hitting .250 with a double and four walks.
• Geraldo Perdomo is hitting .248 with 18 doubles, six triples, nine home runs and 75 walks. He's slugging .376 with an on-base percentage of .357.
• Among all qualifying players, he is 83rd in batting average, 36th in on-base percentage and 115th in slugging percentage.
• Gabriel Moreno leads Arizona in OBP (.385) this season, fueled by 111 hits.
• Moreno has recorded at least one base hit in 14 straight games. During his last 10 games he is hitting .357 with five doubles, a triple, two home runs, four walks and 12 RBIs.
• Nolan Arenado is batting .243 with a .321 OBP and 64 RBI for Arizona this season.
• Arenado heads into this game on a two-game hitting streak. During his last five outings he is hitting .250 with two home runs, a walk and six RBIs.

Reds Player Leaders

• Sal Stewart has racked up 127 hits with a .473 slugging percentage, both team-best numbers for the Reds. He's batting .259 and with an on-base percentage of .334.
• Including all the qualifying hitters in the majors, his batting average is 66th, his on-base percentage ranks 67th, and he is 33rd in slugging.
• Stewart enters this game on a six-game hitting streak. In his last 10 games he is batting .289 with a double, two home runs, three walks and nine RBIs.
• Elly De La Cruz's .340 OBP paces his team. He has a batting average of .257 while slugging .463.
• Including all qualified hitters, his batting average puts him 69th, his on-base percentage ranks 58th, and he is 39th in slugging.
• JJ Bleday is hitting .217 with 13 doubles, a triple, 20 home runs and 59 walks.
• Matt McLain has 17 doubles, 12 home runs and 43 walks while hitting .198.

Diamondbacks vs Reds Head to Head

• 8/21/2026: 9-0 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +132)
• 6/14/2026: 5-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 10, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/13/2026: 2-1 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 6/12/2026: 5-2 ARI (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/24/2025: 6-1 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 8/23/2025: 10-1 ARI (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/22/2025: 6-5 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/8/2025: 4-2 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/7/2025: 13-1 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/15/2024: 2-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)

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