Diamondbacks vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 22

Odds updated as of 5:12 a.m.

The MLB schedule on Saturday includes the Arizona Diamondbacks taking on the Cincinnati Reds.

We've got you covered, in terms of the most important information regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Diamondbacks vs Reds Game Info

• Arizona Diamondbacks (68-61) vs. Cincinnati Reds (61-68)
• Date: Saturday, August 22, 2026
• Time: 8:10 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: Dbacks.TV and Reds.TV

Diamondbacks vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-174) | CIN: (+146)
• Spread: ARI: -1.5 (+126) | CIN: +1.5 (-152)
• Total: 8.5 -- Over: (+100) | Under: (-122)

Diamondbacks vs Reds Probable Starting Pitchers

Probable Pitchers: Mike Soroka (Diamondbacks) - 8-3, 2.93 ERA vs Rhett Lowder (Reds) - 4-8, 5.17 ERA

This contest's pitching matchup is set, as the Diamondbacks will send Mike Soroka (8-3) to the mound, while Rhett Lowder (4-8) will answer the bell for the Reds. Soroka's team is 9-7-0 against the spread this season in his starts. Soroka's team is 7-3 this season when he starts and they are the moneyline favorite. The Reds have gone 9-10-0 against the spread when Lowder starts. The Reds have been the moneyline underdog in 16 of Lowder's starts this season, and they went 8-8 in those games.

Diamondbacks vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (66%)

Diamondbacks vs Reds Moneyline

• Looking at the moneyline for Diamondbacks-Reds, Arizona is the favorite at -174, and Cincinnati is +146 playing on the road.

Diamondbacks vs Reds Spread

• The Reds are +1.5 on the run line against the Diamondbacks. The Reds are -152 to cover, and the Diamondbacks are +126.

Diamondbacks vs Reds Over/Under

• The over/under for Diamondbacks-Reds on Aug. 22 is 8.5. The over is +100, and the under is -122.

Bet on Arizona Diamondbacks vs. Cincinnati Reds on FanDuel today!

Diamondbacks vs Reds Betting Trends

• The Diamondbacks have won in 31, or 59.6%, of the 52 contests they have been named as odds-on favorites in this year.
• This season Arizona has come away with a win five times in six chances when named as a favorite of at least -174 on the moneyline.
• The Diamondbacks' games have gone over the total in 56 of their 128 opportunities.
• The Diamondbacks are 69-59-0 against the spread in their 128 games that had a posted line this season.
• The Reds have been the underdog on the moneyline 84 total times this season. They've gone 39-45 in those games.
• Cincinnati is 3-2 (winning 60% of its games) when it has played as a moneyline underdog of +146 or longer.
• The Reds have played in 126 games with an over/under set, and have combined with their opponents to go over the total 67 times (67-57-2).
• The Reds have put together a 66-60-0 record ATS this season (covering 52.4% of the time).

Diamondbacks Player Leaders

• Corbin Carroll has 116 hits, which ranks first among Arizona hitters this season, while batting .248 with 60 extra-base hits. He has an on-base percentage of .348 and a slugging percentage of .486.
• Among qualifying hitters, he is 84th in batting average, his on-base percentage ranks 49th, and he is 24th in slugging.
• Carroll hopes to build on a two-game hitting streak in this matchup. During his last five outings he is hitting .250 with a double and four walks.
• Geraldo Perdomo is batting .248 with 18 doubles, six triples, nine home runs and 75 walks. He's slugging .376 with an on-base percentage of .357.
• He ranks 84th in batting average, 37th in on-base percentage and 115th in slugging in the major leagues.
• Gabriel Moreno leads Arizona with an OBP of .385 this season while batting .308 with 46 walks and 55 runs scored.
• Moreno has recorded a hit in 14 straight games. During his last 10 outings he is hitting .357 with five doubles, a triple, two home runs, four walks and 12 RBIs.
• Nolan Arenado has 20 home runs, 64 RBI and a batting average of .243 this season.
• Arenado brings a two-game hitting streak into this game. During his last five outings he is hitting .250 with two home runs, a walk and six RBIs.

Reds Player Leaders

• Sal Stewart has a slugging percentage of .473 and has 127 hits, both team-high numbers for the Reds. He's batting .259 and with an on-base percentage of .334.
• Including all the qualified hitters in the big leagues, his batting average is 66th, his on-base percentage ranks 67th, and he is 33rd in slugging.
• Stewart hopes to build on a six-game hitting streak in this matchup. In his last 10 outings he is batting .289 with a double, two home runs, three walks and nine RBIs.
• Elly De La Cruz's .340 OBP leads his team. He has a batting average of .257 while slugging .463.
• Including all qualifying hitters, his batting average puts him 69th, his on-base percentage is 58th, and he is 39th in slugging.
• JJ Bleday is batting .217 with 13 doubles, a triple, 20 home runs and 59 walks.
• Matt McLain is hitting .198 with 17 doubles, 12 home runs and 43 walks.

Diamondbacks vs Reds Head to Head

• 8/21/2026: 9-0 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +132)
• 6/14/2026: 5-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 10, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/13/2026: 2-1 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 6/12/2026: 5-2 ARI (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/24/2025: 6-1 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 8/23/2025: 10-1 ARI (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/22/2025: 6-5 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/8/2025: 4-2 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/7/2025: 13-1 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/15/2024: 2-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!