Clemson vs Penn State Prediction, Odds, Picks, Best Bets for Pinstripe Bowl 2025

Saturday's slate in college football includes a matchup between the Clemson Tigers and the Penn State Nittany Lions.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Clemson vs Penn State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Clemson: (-144) | Penn State: (+124)
• Spread: Clemson: -2.5 (-118) | Penn State: +2.5 (-104)
• Total: 47.5 -- Over: (-104) | Under: (-118)

Clemson vs Penn State Betting Trends

• Against the spread, Clemson is 5-7-0 this year.
• Clemson has two wins ATS (2-7) as a 2.5-point or higher favorite in 2025.
• Out of 12 Clemson games so far this season, five have gone over the total.
• Penn State has beaten the spread four times in 12 games.
• As a 2.5-point underdog or greater, Penn State has two wins ATS (2-1).
• Penn State has seen nine of its 12 games hit the over.

Clemson vs Penn State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Nittany Lions win (59.9%)

Clemson vs Penn State Point Spread

Penn State is a 2.5-point underdog against Clemson. Penn State is -104 to cover the spread, and Clemson is -118.

Clemson vs Penn State Over/Under

An over/under of 47.5 has been set for Clemson-Penn State on Dec. 27, with the over being -104 and the under -118.

Clemson vs Penn State Moneyline

Penn State is the underdog, +124 on the moneyline, while Clemson is a -144 favorite.

Clemson vs. Penn State Points Insights

Clemson vs. Penn State Game Info

• Game day: Saturday, December 27, 2025
• Game time: 12 p.m. ET
• TV channel: ABC
• Location: The Bronx, New York
• Stadium: Yankee Stadium

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Check out even more in-depth Clemson vs. Penn State analysis on FanDuel Research.