Clemson vs Penn State Prediction, Odds, Picks, Best Bets for Pinstripe Bowl 2025

The Saturday schedule in college football includes a matchup between the Clemson Tigers and the Penn State Nittany Lions.

We've got you covered, in terms of the most important information regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Clemson vs Penn State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Clemson: (-138) | Penn State: (+118)
• Spread: Clemson: -2.5 (-115) | Penn State: +2.5 (-105)
• Total: 47.5 -- Over: (-115) | Under: (-105)

Clemson vs Penn State Betting Trends

• Against the spread, Clemson is 5-7-0 this year.
• As at least a 2.5-point favorite, Clemson has two wins ATS (2-7).
• There have been five Clemson games (of 12) that went over the total this year.
• Penn State has four wins in 12 contests against the spread this season.
• Penn State has two wins ATS (2-1) as a 2.5-point underdog or more this year.
• Penn State has seen nine of its 12 games go over the point total.

Clemson vs Penn State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Nittany Lions win (59.9%)

Clemson vs Penn State Point Spread

Penn State is listed as an underdog by 2.5 points (-105 odds), and Clemson, the favorite, is -115 to cover.

Clemson vs Penn State Over/Under

A total of 47.5 points has been set for the Clemson-Penn State game on Dec. 27, with the over available at -115 and the under at -105.

Clemson vs Penn State Moneyline

The Clemson vs Penn State moneyline has Clemson as a -138 favorite, while Penn State is a +118 underdog.

Clemson vs. Penn State Points Insights

Clemson vs. Penn State Game Info

• Game day: Saturday, December 27, 2025
• Game time: 12 p.m. ET
• TV channel: ABC
• Location: The Bronx, New York
• Stadium: Yankee Stadium

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Check out even more in-depth Clemson vs. Penn State analysis on FanDuel Research.