Clemson vs North Carolina Prediction, Odds, Picks, Best Bets for Week 3 2026

The college football schedule on Saturday includes the Clemson Tigers taking on the North Carolina Tar Heels.

Get the latest NCAA football odds ahead of this game on FanDuel Sportsbook.

Clemson vs North Carolina Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Clemson: (-164) | North Carolina: (+136)
• Spread: Clemson: -3.5 (-102) | North Carolina: +3.5 (-120)
• Total: 44.5 -- Over: (-105) | Under: (-115)

Clemson vs North Carolina Betting Trends

• Clemson has no wins against the spread this year.
• Clemson is winless ATS (0-1) as a 3.5-point favorite or greater this season.
• One of Clemson's two games this season has gone over the point total.
• North Carolina has but one win versus the spread this season.
• North Carolina has yet to lose ATS (1-0) as a 3.5-point underdog or more this season.
• North Carolina and its opponent have yet to go over the total this season.

Clemson vs North Carolina Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Tigers win (67.8%)

Clemson vs North Carolina Point Spread

North Carolina is a 3.5-point underdog against Clemson. North Carolina is -120 to cover the spread, and Clemson is -102.

Clemson vs North Carolina Over/Under

A combined point total of 44.5 has been set for Clemson-North Carolina on Sept. 19, with the over at -105 and the under at -115.

Clemson vs North Carolina Moneyline

The Clemson vs North Carolina moneyline has Clemson as a -164 favorite, while North Carolina is a +136 underdog.

Clemson vs. North Carolina Points Insights

Clemson vs. North Carolina Game Info

• Game day: Saturday, September 19, 2026
• Game time: 12 p.m. ET
• TV channel: ESPN
• Location: Clemson, South Carolina
• Stadium: Memorial Stadium (Clemson, SC)

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Check out even more in-depth Clemson vs. North Carolina analysis on FanDuel Research.