Cardinals vs Seahawks Prediction, Odds, Picks, Best Bets for NFL Week 4 Thursday Night Football

On Thursday in the NFL, the Arizona Cardinals are up against the Seattle Seahawks.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important information about today's NFL betting odds.

Cardinals vs Seahawks Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction:

Cardinals vs Seahawks Point Spread

The Cardinals are 1.5-point favorites against the Seahawks. The Cardinals are +100 to cover the spread, while the Seahawks are -122 to cover as a 1.5-point underdog.

Cardinals vs Seahawks Over/Under

Cardinals versus Seahawks on Sept. 25 has an over/under of 43.5 points, with the over -102 and the under -120.

Cardinals vs Seahawks Moneyline

The Cardinals vs Seahawks moneyline has Arizona as a -118 favorite, while Seattle is a +100 underdog on the road.

Cardinals vs Seahawks Betting Trends

• Arizona has posted two wins against the spread this year.
• The Cardinals have one win ATS (1-1) as a 1.5-point favorite or greater this year.
• The Cardinals have had one game (out of three) go over the total this season.
• The Seahawks have won twice against the spread this season.
• Seattle has one win ATS (1-1) as a 1.5-point underdog or more this year.
• Two of the Seahawks' three games in 2025 have gone over the point total.

Check out even more in-depth Cardinals vs. Seahawks analysis on FanDuel Research.

Cardinals vs Seahawks Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-118) | SEA: (+100)
• Spread: ARI: -1.5 (100) | SEA: +1.5 (-122)
• Total: 43.5 -- Over: (-102) | Under: (-120)

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