Cardinals vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 20

Odds updated as of 2:12 p.m.

MLB action on Sunday includes the St. Louis Cardinals facing the Washington Nationals.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Cardinals vs Nationals Game Info

• St. Louis Cardinals (75-80) vs. Washington Nationals (73-82)
• Date: Sunday, September 20, 2026
• Time: 2:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and Nationals.TV

Cardinals vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-130) | WSH: (+110)
• Spread: STL: -1.5 (+146) | WSH: +1.5 (-176)
• Total: 8.5 -- Over: (-122) | Under: (+100)

Cardinals vs Nationals Probable Starting Pitchers

Probable Pitchers: Quinn Mathews (Cardinals) - 2-3, 3.62 ERA vs Jake Irvin (Nationals) - 2-9, 5.51 ERA

The probable pitchers are Quinn Mathews (2-3) for the Cardinals and Jake Irvin (2-9) for the Nationals. Mathews and his team are 2-5-0 ATS this season when he starts. Mathews' team has been victorious in 66.7% of the games he's started as the moneyline favorite with a record of 2-1. The Nationals have a 12-7-0 record against the spread in Irvin's starts. The Nationals are 7-10 in Irvin's 17 starts this season that they were the moneyline underdog.

Cardinals vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (55.4%)

Cardinals vs Nationals Moneyline

• Washington is the underdog, +110 on the moneyline, while St. Louis is a -130 favorite at home.

Cardinals vs Nationals Spread

• The Cardinals are favored by 1.5 runs at home against the Nationals. The Cardinals are +146 to cover the spread, while the Nationals are -176.

Cardinals vs Nationals Over/Under

• The over/under for the Cardinals versus Nationals game on Sept. 20 has been set at 8.5, with -122 odds on the over and +100 odds on the under.

Bet on St. Louis Cardinals vs. Washington Nationals on FanDuel today!

Cardinals vs Nationals Betting Trends

• The Cardinals have been favorites in 51 games this season and have come away with the win 27 times (52.9%) in those contests.
• This season St. Louis has been victorious nine times in 17 chances when named as a favorite of at least -130 on the moneyline.
• The Cardinals and their opponents have gone over the total this season in 71 of their 151 opportunities.
• In 151 games with a line this season, the Cardinals have a mark of 80-71-0 against the spread.
• The Nationals have put together a 49-66 record in games they were listed as the moneyline underdog (winning 42.6% of those games).
• In games it has played as a moneyline underdog with odds of +110 or longer, Washington has a record of 35-51 (40.7%).
• In the 151 games oddsmakers have set an over/under for the Nationals, they have combined with opponents to go over the total 80 times (80-65-6).
• The Nationals have an 83-68-0 record ATS this season (covering 55% of the time).

Cardinals Player Leaders

• Alec Burleson leads St. Louis with a slugging percentage of .469, fueled by 61 extra-base hits. He has a .284 batting average and an on-base percentage of .349.
• Among qualified batters in the majors, his batting average ranks 18th, his on-base percentage ranks 45th, and he is 32nd in slugging.
• Jordan Walker leads St. Louis with 161 hits. He is batting .276 this season and has 61 extra-base hits. He's also slugging .476 with an on-base percentage of .333.
• Among all qualifying hitters, he ranks 32nd in batting average, 65th in on-base percentage and 29th in slugging percentage.
• Ivan Herrera leads St. Louis in OBP (.358) this season, fueled by 142 hits.
• Herrera has recorded at least one base hit in two games in a row. During his last five outings he is hitting .286 with a double, two walks and two RBIs.
• JJ Wetherholt is batting .242 with a .342 OBP and 49 RBI for St. Louis this season.
• Wetherholt heads into this game on a two-game hitting streak. During his last five outings he is hitting .125 with an RBI.

Nationals Player Leaders

• C.J. Abrams has a .488 slugging percentage, which leads the Nationals. He's batting .261 with an on-base percentage of .337.
• Including all qualifying players in MLB, he ranks 60th in batting average, 59th in on-base percentage and 19th in slugging percentage.
• James Wood has racked up 130 hits with a .392 OBP to pace his team in both. He has a batting average of .267 while slugging .517.
• He ranks 48th in batting average, third in on-base percentage and 10th in slugging percentage in the big leagues.
• Daylen Lile is hitting .249 with 27 doubles, eight triples, 22 home runs and 40 walks.
• Jacob Young is batting .248 with 21 doubles, three triples, 10 home runs and 33 walks.

Cardinals vs Nationals Head to Head

• 9/19/2026: 8-5 WSH (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/18/2026: 9-1 WSH (Favorite: Nationals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/8/2026: 6-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/7/2026: 7-6 STL (Favorite: Nationals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/6/2026: 9-6 WSH (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/10/2025: 8-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/9/2025: 8-2 WSH (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/11/2025: 6-1 STL (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/10/2025: 4-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/9/2025: 10-0 STL (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)

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