Cardinals vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 9

Odds updated as of 11:12 p.m.

The Wednesday schedule in MLB includes a matchup between the St. Louis Cardinals and the San Francisco Giants.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Giants Game Info

• St. Louis Cardinals (72-73) vs. San Francisco Giants (60-85)
• Date: Wednesday, September 9, 2026
• Time: 3:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and Cardinals.TV

Cardinals vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-110) | SF: (-106)
• Spread: STL: -1.5 (+138) | SF: +1.5 (-166)
• Total: 7.5 -- Over: (-120) | Under: (-102)

Cardinals vs Giants Probable Starting Pitchers

Probable Pitchers: Andre Pallante (Cardinals) - 12-6, 3.51 ERA vs Matt Wilkinson (Giants) - 0-3, 6.14 ERA

The Cardinals will call on Andre Pallante (12-6) against the Giants and Matt Wilkinson (0-3). Pallante's team is 14-10-0 against the spread in his starts this season. When Pallante starts a game and his team is the favorite on the moneyline, they have a record of 5-6. The Giants have a 2-2-0 ATS record in Wilkinson's four starts that had a set spread. The Giants have been the underdog on the moneyline in four of Wilkinson's starts this season, and they went 1-3 in those matchups.

Cardinals vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (51.1%)

Cardinals vs Giants Moneyline

• The moneyline numbers for Cardinals vs. Giants reveal St. Louis as the favorite (-110) and San Francisco as the underdog (-106) despite being the home team.

Cardinals vs Giants Spread

• The Giants are hosting the Cardinals, and are +1.5 on the runline. The Giants are +138 to cover the spread, and the Cardinals are -166.

Cardinals vs Giants Over/Under

• An over/under of 7.5 has been set for Cardinals-Giants on Sept. 9, with the over being -120 and the under -102.

Bet on St. Louis Cardinals vs. San Francisco Giants on FanDuel today!

Cardinals vs Giants Betting Trends

• The Cardinals have been chosen as favorites in 45 games this year and have walked away with the win 25 times (55.6%) in those games.
• This year St. Louis has won 24 of 44 games when listed as at least -110 on the moneyline.
• Contests with the Cardinals have gone over the total set by oddsmakers in 64 of 141 chances this season.
• In 141 games with a line this season, the Cardinals have a mark of 77-64-0 against the spread.
• The Giants have gone 35-61 in games they were listed as the moneyline underdog (winning 36.5% of those games).
• When it has played as a moneyline underdog with odds of -106 or longer, San Francisco has a 33-58 record (winning just 36.3% of its games).
• The Giants have played in 142 games with an over/under set, and have combined with their opponents to go over the total 68 times (68-64-10).
• The Giants have gone 67-75-0 ATS this season.

Cardinals Player Leaders

• Alec Burleson has 34 doubles, a triple, 22 home runs and 48 walks while batting .283. He has an on-base percentage of .344 and a slugging percentage of .467.
• Among all qualifying batters in the majors, he ranks 16th in batting average, 46th in on-base percentage, and 36th in slugging.
• Burleson will look for his fifth straight game with a hit in this matchup. In his last five games he is batting .273 with a double, a home run and three RBIs.
• Jordan Walker leads St. Louis in slugging percentage (.494) and total hits (157) this season. He's batting .284 with an on-base percentage of .340.
• Among all qualified, he ranks 15th in batting average, 51st in on-base percentage and 17th in slugging percentage.
• Ivan Herrera has 137 hits this season and a team-best OBP of .362.
• Herrera takes a five-game hitting streak into this game. During his last five outings he is hitting .435 with a double, two home runs, a walk and eight RBIs.
• Nathan Church has 10 home runs, 49 RBI and a batting average of .243 this season.
• Church brings a seven-game hitting streak into this game. In his last 10 games he is batting .237 with a double and four RBIs.

Giants Player Leaders

• Rafael Devers has accumulated an on-base percentage of .342, a slugging percentage of .522, and has 142 hits, all club-bests for the Giants (while batting .260).
• Including all the qualifying players in the majors, his batting average puts him 61st, his on-base percentage ranks 50th, and he is eighth in slugging.
• Devers brings a four-game hitting streak into this matchup. During his last five outings he is batting .421 with four doubles, three home runs, three walks and nine RBIs.
• Jung Hoo Lee is hitting .280 with 28 doubles, four triples, nine home runs and 27 walks. He's slugging .406 with an on-base percentage of .323.
• Including all qualifying hitters, he is 26th in batting average, 81st in on-base percentage and 85th in slugging percentage.
• Bryce Eldridge has 21 doubles, 15 home runs and 54 walks while hitting .265.
• Drew Gilbert has 13 doubles, three triples, eight home runs and 34 walks while batting .231.

Cardinals vs Giants Head to Head

• 9/7/2026: 5-4 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/24/2025: 4-3 SF (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/23/2025: 9-8 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 9/22/2025: 6-5 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/7/2025: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/6/2025: 3-2 STL (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 9/5/2025: 8-2 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/29/2024: 6-1 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/28/2024: 6-5 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/27/2024: 6-3 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)

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