Cardinals vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 9

Odds updated as of 3:12 p.m.

The MLB schedule on Wednesday includes the St. Louis Cardinals taking on the San Francisco Giants.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Giants Game Info

• St. Louis Cardinals (72-74) vs. San Francisco Giants (61-85)
• Date: Wednesday, September 9, 2026
• Time: 3:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and Cardinals.TV

Cardinals vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-110) | SF: (-106)
• Spread: STL: -1.5 (+138) | SF: +1.5 (-166)
• Total: 7.5 -- Over: (-120) | Under: (-102)

Cardinals vs Giants Probable Starting Pitchers

Probable Pitchers: Andre Pallante (Cardinals) - 12-6, 3.51 ERA vs Blade Tidwell (Giants) - 0-2, 4.43 ERA

The Cardinals will call on Andre Pallante (12-6) against the Giants and Blade Tidwell (0-2). Pallante and his team have a record of 14-10-0 against the spread when he starts. Pallante's team has been victorious in 45.5% of the games he's started as the moneyline favorite with a record of 5-6. The Giants have a 2-4-0 ATS record in Tidwell's six starts that had a set spread. The Giants were named the moneyline underdog for five Tidwell starts this season -- they lost each time.

Cardinals vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (51.2%)

Cardinals vs Giants Moneyline

• San Francisco is the underdog, -106 on the moneyline, while St. Louis is a -110 favorite despite being on the road.

Cardinals vs Giants Spread

• The Cardinals are at the Giants and are favored by 1.5 runs on the spread. The Cardinals are +138 to cover the runline, with the Giants being -166.

Cardinals vs Giants Over/Under

• An over/under of 7.5 has been set for Cardinals-Giants on Sept. 9, with the over being -120 and the under -102.

Bet on St. Louis Cardinals vs. San Francisco Giants on FanDuel today!

Cardinals vs Giants Betting Trends

• The Cardinals have been chosen as favorites in 46 games this year and have walked away with the win 25 times (54.3%) in those games.
• St. Louis has a record of 24-21 in contests when bookmakers favor them by -110 or more on the moneyline.
• The Cardinals' games have gone over the total in 64 of their 142 opportunities.
• The Cardinals have an against the spread record of 77-65-0 in 142 games with a line this season.
• The Giants have won 36 of the 97 games they were the moneyline underdog this season (37.1%).
• San Francisco has a 33-58 record (winning just 36.3% of its games) when it has played as a moneyline underdog of -106 or longer.
• The Giants have combined with opponents to hit the over on the total 68 times this season for a 68-65-10 record against the over/under.
• The Giants have put together a 68-75-0 record ATS this season.

Cardinals Player Leaders

• Alec Burleson leads St. Louis with a slugging percentage of .468, fueled by 57 extra-base hits. He has a .284 batting average and an on-base percentage of .349.
• Among qualified batters, he ranks 16th in batting average, his on-base percentage ranks 41st, and he is 34th in slugging.
• Burleson hopes to build on a five-game hitting streak in this matchup. During his last five outings he is batting .333 with a double, a home run, three walks and three RBIs.
• Jordan Walker leads St. Louis with 157 hits and a team-best slugging percentage of .490. He's batting .282 with an on-base percentage of .338.
• Among qualified hitters, he is 19th in batting average, 53rd in on-base percentage and 19th in slugging percentage.
• Ivan Herrera leads St. Louis in OBP (.361) this season, fueled by 138 hits.
• Herrera has picked up a hit in six games in a row. During his last 10 outings he is batting .341 with two doubles, two home runs, four walks and 11 RBIs.
• Nathan Church is batting .243 with a .286 OBP and 49 RBI for St. Louis this season.
• Church has safely hit in eight straight games. In his last 10 outings he is batting .263 with a double, a walk and three RBIs.

Giants Player Leaders

• Rafael Devers has totaled 142 hits with a .340 on-base percentage and a .518 slugging percentage, all club-highs for the Giants. He's batting .258.
• Including all the qualified hitters in MLB, he ranks 64th in batting average, 51st in on-base percentage and 10th in slugging percentage.
• Jung Hoo Lee has 28 doubles, four triples, nine home runs and 27 walks while hitting .279. He's slugging .405 with an on-base percentage of .323.
• Including all qualifying hitters, his batting average places him 26th, his on-base percentage is 80th, and he is 86th in slugging.
• Bryce Eldridge has 21 doubles, 16 home runs and 55 walks while hitting .265.
• Drew Gilbert is hitting .231 with 13 doubles, three triples, eight home runs and 34 walks.

Cardinals vs Giants Head to Head

• 9/8/2026: 2-1 SF (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/7/2026: 5-4 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/24/2025: 4-3 SF (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/23/2025: 9-8 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 9/22/2025: 6-5 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/7/2025: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/6/2025: 3-2 STL (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 9/5/2025: 8-2 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/29/2024: 6-1 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/28/2024: 6-5 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)

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