Brewers vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 4

Odds updated as of 5:13 p.m.

Friday's slate in the MLB includes a matchup between the Milwaukee Brewers and the Cincinnati Reds.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Brewers vs Reds Game Info

• Milwaukee Brewers (87-54) vs. Cincinnati Reds (67-73)
• Date: Friday, September 4, 2026
• Time: 6:10 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Reds.TV and Brewers.TV

Brewers vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-154) | CIN: (+130)
• Spread: MIL: -1.5 (+104) | CIN: +1.5 (-125)
• Total: 9.5 -- Over: (-110) | Under: (-110)

Brewers vs Reds Probable Starting Pitchers

Probable Pitchers: Shane Drohan (Brewers) - 7-5, 3.75 ERA vs Rhett Lowder (Reds) - 6-8, 5.14 ERA

The Brewers will give the nod to Shane Drohan (7-5, 3.75 ERA), who is eyeing win No. 8 on the season, and the Reds will turn to Rhett Lowder (6-8, 5.14 ERA). Drohan's team is 7-9-0 against the spread this season in his starts. Drohan's team has a record of 8-6 this season when he starts and they are the favorite on the moneyline. The Reds have an 11-10-0 record against the spread in Lowder's starts. The Reds have been the underdog on the moneyline in 18 of Lowder's starts this season, and they went 10-8 in those matchups.

Brewers vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (68.6%)

Brewers vs Reds Moneyline

• Milwaukee is the favorite, -154 on the moneyline, while Cincinnati is a +130 underdog despite being at home.

Brewers vs Reds Spread

• The Reds are +1.5 on the spread (-125 to cover), and Milwaukee is +104 to cover the runline.

Brewers vs Reds Over/Under

• A combined run total of 9.5 has been set for Brewers-Reds on Sept. 4, with the over at -110 and the under at -110.

Bet on Milwaukee Brewers vs. Cincinnati Reds on FanDuel today!

Brewers vs Reds Betting Trends

• The Brewers have been favorites in 108 games this season and have come away with the win 69 times (63.9%) in those contests.
• Milwaukee has a record of 32-17 in contests when sportsbooks favor them by -154 or more on the moneyline.
• The Brewers and their opponents have hit the over in 61 of their 141 games with a total set by oddsmakers this season.
• The Brewers are 74-67-0 against the spread in their 141 games that had a posted line this season.
• The Reds have been the underdog on the moneyline 93 total times this season. They've finished 45-48 in those games.
• When it has played as a moneyline underdog with odds of +130 or longer, Cincinnati has gone 11-16 (40.7%).
• The Reds have combined with opponents to hit the over on the total 73 times this season for a 73-62-2 record against the over/under.
• The Reds have a 71-66-0 record against the spread this season (covering 51.8% of the time).

Brewers Player Leaders

• Brice Turang is hitting .252 with 29 doubles, three triples, 17 home runs and 74 walks. He has an on-base percentage of .346 and a slugging percentage of .421.
• Among all qualifying hitters, he is 75th in batting average, his on-base percentage ranks 44th, and he is 68th in slugging.
• Jake Bauers leads the Brewers in OBP (.389) and total hits (113) this season. He's batting .268 while slugging .487.
• He is 47th in batting average, fourth in on-base percentage and 19th in slugging in the majors.
• William Contreras has hit 13 homers with a team-high .402 SLG this season.
• Jackson Chourio has been key for Milwaukee with 125 hits, an OBP of .344 plus a slugging percentage of .483.

Reds Player Leaders

• Sal Stewart has totaled 143 hits with a .485 slugging percentage, both team-best statistics for the Reds. He's batting .266 and with an on-base percentage of .336.
• He is 52nd in batting average, 62nd in on-base percentage and 22nd in slugging percentage among all qualifying hitters in MLB.
• Elly De La Cruz's .353 OBP leads his team. He has a batting average of .273 while slugging .476.
• Including all qualifying players, his batting average places him 37th, his on-base percentage is 38th, and he is 29th in slugging.
• JJ Bleday is batting .222 with 15 doubles, two triples, 22 home runs and 64 walks.
• Tyler Stephenson is hitting .249 with 19 doubles, 14 home runs and 42 walks.

Brewers vs Reds Head to Head

• 7/2/2026: 7-2 CIN (Favorite: Brewers, Spread: -1.5, Total: 7, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 7/1/2026: 4-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/30/2026: 7-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/29/2026: 5-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/24/2026: 6-5 MIL (Favorite: Brewers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/23/2026: 2-0 MIL (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/22/2026: 2-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/28/2025: 4-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/27/2025: 7-4 CIN (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 9/26/2025: 3-1 CIN (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)

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