Brewers vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 17

Odds updated as of 12:12 p.m.

The Milwaukee Brewers are among the MLB squads in action on Thursday, versus the Pittsburgh Pirates.

All the information you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Brewers vs Pirates Game Info

• Milwaukee Brewers (95-57) vs. Pittsburgh Pirates (75-77)
• Date: Thursday, September 17, 2026
• Time: 12:35 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and Brewers.TV

Brewers vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-132) | PIT: (+112)
• Spread: MIL: -1.5 (+122) | PIT: +1.5 (-146)
• Total: 8.5 -- Over: (-120) | Under: (-102)

Brewers vs Pirates Probable Starting Pitchers

Probable Pitchers: Kyle Harrison (Brewers) - 10-4, 3.98 ERA vs Wilber Dotel (Pirates) - 1-5, 4.84 ERA

The Brewers will give the ball to Kyle Harrison (10-4, 3.98 ERA), who is eyeing win No. 11 on the season, and the Pirates will turn to Wilber Dotel (1-5, 4.84 ERA). Harrison's team is 14-9-0 against the spread in his starts this season. Harrison's team has a record of 9-8 this season when he starts and they are the favorite on the moneyline. Dotel has started only one game with a set spread, which the Pirates failed to cover. The Pirates were named the moneyline underdog for one Dotel start this season -- they lost.

Brewers vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (50.5%)

Brewers vs Pirates Moneyline

• Milwaukee is the favorite, -132 on the moneyline, while Pittsburgh is a +112 underdog despite being at home.

Brewers vs Pirates Spread

• The Pirates are hosting the Brewers, and are +1.5 on the runline. The Pirates are +122 to cover the spread, and the Brewers are -146.

Brewers vs Pirates Over/Under

• A total of 8.5 runs has been set for the Brewers-Pirates game on Sept. 17, with the over available at -120 and the under at -102.

Bet on Milwaukee Brewers vs. Pittsburgh Pirates on FanDuel today!

Brewers vs Pirates Betting Trends

• The Brewers have come away with 76 wins in the 118 contests they have been listed as the favorites in this season.
• Milwaukee has a record of 55-30 when favored by -132 or more this year.
• The Brewers and their opponents have hit the over in 66 of their 151 games with a total set by oddsmakers this season.
• The Brewers have posted a record of 79-72-0 against the spread this season.
• The Pirates have been the moneyline underdog 72 total times this season. They've finished 31-41 in those games.
• Pittsburgh has gone 16-23 when playing as a moneyline underdog with odds of +112 or longer (41%).
• In the 150 games oddsmakers have set an over/under for the Pirates, they have combined with opponents to go over the total 78 times (78-68-4).
• The Pirates have a 73-77-0 record ATS this season.

Brewers Player Leaders

• Brice Turang is hitting .267 with 34 doubles, three triples, 19 home runs and 88 walks. He has an on-base percentage of .369 while slugging .445.
• He ranks 52nd in batting average, 18th in on-base percentage, and 50th in slugging among qualified hitters in MLB.
• William Contreras has an OPS of .759, fueled by an OBP of .341 and a team-best slugging percentage of .418 this season. He's batting .271.
• Among qualifying hitters, his batting average places him 40th, his on-base percentage 54th, and his slugging percentage 77th.
• Contreras brings a six-game streak with at least one hit into this matchup. In his last 10 games he is batting .238 with two doubles, four home runs, five walks and 14 RBIs.
• Jake Bauers leads his team in OBP (.394) and total hits (121) this season.
• Bauers enters this game with five games in a row with at least one hit. During his last five outings he is hitting .300 with a double, two home runs, three walks and five RBIs.
• Jackson Chourio has been key for Milwaukee with 141 hits, an OBP of .345 plus a slugging percentage of .485.

Pirates Player Leaders

• Bryan Reynolds is hitting .262 with 36 doubles, two triples, 17 home runs and 84 walks. He's slugging .423 with an on-base percentage of .366.
• He ranks 61st in batting average, 21st in on-base percentage and 73rd in slugging percentage among all qualifying hitters in MLB.
• Brandon Lowe has 143 hits to pace his team. He has a batting average of .260 while slugging .484 with an on-base percentage of .329.
• He is currently 65th in batting average, 70th in on-base percentage and 23rd in slugging percentage among all qualified hitters.
• Nick Gonzales has racked up an on-base percentage of .370 and a slugging percentage of .395. Both lead the Pirates.
• Ryan O'Hearn has 15 doubles, 18 home runs and 32 walks while hitting .269.

Brewers vs Pirates Head to Head

• 9/16/2026: 5-4 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/15/2026: 5-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/6/2026: 5-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: +110)
• 8/5/2026: 4-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7, Favorite Moneyline: -124, Underdog Moneyline: +114)
• 8/4/2026: 4-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +132)
• 8/3/2026: 4-3 PIT (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +136)
• 7/12/2026: 14-5 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/11/2026: 3-2 PIT (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/11/2026: 7-6 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/26/2026: 5-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!