Blue Jays vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 2:11 p.m.

In MLB action on Saturday, the Toronto Blue Jays face the Cincinnati Reds.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Blue Jays vs Reds Game Info

• Toronto Blue Jays (78-82) vs. Cincinnati Reds (74-86)
• Date: Saturday, September 26, 2026
• Time: 3:07 p.m. ET
• Venue: Rogers Centre -- Toronto, Ontario
• Coverage: SNET and Reds.TV

Blue Jays vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TOR: (-162) | CIN: (+136)
• Spread: TOR: -1.5 (+134) | CIN: +1.5 (-162)
• Total: 8.5 -- Over: (+100) | Under: (-122)

Blue Jays vs Reds Probable Starting Pitchers

Probable Pitchers: Trey Yesavage (Blue Jays) - 5-5, 3.67 ERA vs Rhett Lowder (Reds) - 6-12, 6.01 ERA

This contest's pitching matchup is set, as the Blue Jays will send Trey Yesavage (5-5) to the mound, while Rhett Lowder (6-12) will get the nod for the Reds. Yesavage's team is 5-12-0 against the spread this season in his starts. Yesavage's team has a record of 5-5 this season when he starts and they are the favorite on the moneyline. The Reds have an 11-13-0 ATS record in Lowder's 24 starts that had a set spread. The Reds have a 10-11 record in Lowder's 21 starts this season when they were the underdog on the moneyline.

Blue Jays vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Blue Jays win (57.2%)

Blue Jays vs Reds Moneyline

• The moneyline numbers for Blue Jays vs. Reds reveal Toronto as the favorite (-162) and Cincinnati as the underdog (+136) on the road.

Blue Jays vs Reds Spread

• The Blue Jays are 1.5-run home favorites on the runline against the Reds. The Blue Jays are +134 to cover, and the Reds are -162.

Blue Jays vs Reds Over/Under

• An over/under of 8.5 has been set for Blue Jays-Reds on Sept. 26, with the over being +100 and the under -122.

Bet on Toronto Blue Jays vs. Cincinnati Reds on FanDuel today!

Blue Jays vs Reds Betting Trends

• The Blue Jays have been favorites in 79 games this season and have come away with the win 42 times (53.2%) in those contests.
• This season Toronto has been victorious seven times in 16 chances when named as a favorite of at least -162 on the moneyline.
• Contests with the Blue Jays have gone over the total set by bookmakers in 81 of 155 chances this season.
• The Blue Jays have an against the spread record of 74-81-0 in 155 games with a line this season.
• The Reds have been the moneyline underdog 112 total times this season. They've gone 52-60 in those games.
• When playing as a moneyline underdog with odds of +136 or longer, Cincinnati has a record of 13-17 (43.3%).
• The Reds have combined with opponents to hit the over on the total 83 times this season for an 83-71-2 record against the over/under.
• The Reds have collected an 81-75-0 record against the spread this season.

Blue Jays Player Leaders

• Kazuma Okamoto has 132 hits, which ranks first among Toronto hitters this season, while batting .234 with 59 extra-base hits. He has an on-base percentage of .310 and a slugging percentage of .456.
• Among all qualified hitters in MLB, his batting average ranks 107th, his on-base percentage ranks 103rd, and he is 41st in slugging.
• Vladimir Guerrero Jr. leads Toronto in OBP (.334) this season, fueled by 141 hits. He's batting .262 while slugging .359.
• His batting average is 58th among qualified players, his on-base percentage 61st, and his slugging percentage 125th.
• Guerrero has picked up a hit in six straight games. In his last 10 outings he is batting .297 with three doubles, a home run, four walks and three RBIs.
• Ernie Clement has hit nine homers with a team-high .368 SLG this season.
• George Springer has 15 home runs, 54 RBI and a batting average of .248 this season.

Reds Player Leaders

• Sal Stewart has accumulated a team-best .463 slugging percentage. He's batting .265 with an on-base percentage of .333.
• Including all the qualifying hitters in the big leagues, his batting average puts him 48th, his on-base percentage ranks 63rd, and he is 37th in slugging.
• Elly De La Cruz leads his team with 157 hits and a .367 on-base percentage. He has a batting average of .285 while slugging .521.
• He is currently 16th in batting average, 19th in on-base percentage and seventh in slugging percentage among all qualifying hitters.
• JJ Bleday is hitting .214 with 16 doubles, two triples, 23 home runs and 71 walks.
• Eugenio Suarez has 17 doubles, 26 home runs and 52 walks while batting .212.

Blue Jays vs Reds Head to Head

• 9/25/2026: 6-5 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/3/2025: 13-9 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/2/2025: 12-9 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/1/2025: 5-4 CIN (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/21/2024: 11-7 CIN (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/20/2024: 10-3 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/19/2024: 6-3 CIN (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/20/2023: 10-3 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/19/2023: 4-3 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 9.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/18/2023: 1-0 CIN (Favorite: Blue Jays, Spread: -1.5, Total: 10, Favorite Moneyline: -144, Underdog Moneyline: +122)

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