Astros vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 3

Odds updated as of 10:12 p.m.

On Thursday in MLB, the Houston Astros are up against the Chicago White Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding this game.

Astros vs White Sox Game Info

• Houston Astros (70-69) vs. Chicago White Sox (73-65)
• Date: Thursday, September 3, 2026
• Time: 2:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and CHSN

Astros vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-142) | CHW: (+120)
• Spread: HOU: -1.5 (+146) | CHW: +1.5 (-178)
• Total: 8.5 -- Over: (-114) | Under: (-106)

Astros vs White Sox Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 4-3, 3.33 ERA vs Luis Castillo (White Sox) - 4-10, 5.31 ERA

This contest's pitching matchup is set, as the Astros will send Hunter Brown (4-3) to the mound, while Luis Castillo (4-10) will take the ball for the White Sox. When Brown starts, his team is 7-8-0 against the spread this season. Brown's team has a record of 6-7 this season when he starts and they are the favorite on the moneyline. The White Sox are 8-14-0 against the spread when Castillo starts. The White Sox have a 3-6 record in Castillo's nine starts this season when they were the underdog on the moneyline.

Astros vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (55.2%)

Astros vs White Sox Moneyline

• Houston is the favorite, -142 on the moneyline, while Chicago is a +120 underdog on the road.

Astros vs White Sox Spread

• The White Sox are +1.5 on the spread (-178 to cover), and Houston is +146 to cover the runline.

Astros vs White Sox Over/Under

• The Astros-White Sox contest on Sept. 3 has been given an over/under of 8.5 runs. The over is set at -114 and the under at -106.

Bet on Houston Astros vs. Chicago White Sox on FanDuel today!

Astros vs White Sox Betting Trends

• The Astros have come away with 30 wins in the 59 contests they have been listed as the favorites in this season.
• Houston has a record of 8-17 when favored by -142 or more this year.
• The Astros and their opponents have hit the over in 72 of their 139 games with a total set by oddsmakers this season.
• The Astros are 67-72-0 against the spread in their 139 games with a line set by sportsbooks this season.
• The White Sox have won 49 of the 99 games they were listed as the moneyline underdog this season (49.5%).
• In games it has played as a moneyline underdog with odds of +120 or longer, Chicago has a record of 25-30 (45.5%).
• The White Sox have played in 135 games with a set over/under, and have combined with their opponents to go over the total 75 times (75-59-1).
• The White Sox have collected a 79-56-0 record against the spread this season.

Astros Player Leaders

• Yordan Alvarez has 155 hits and an OBP of .433 to go with a slugging percentage of .603. All three of those stats are tops among Houston hitters this season. He has a .316 batting average, as well.
• Among all qualifying hitters, he is first in batting average, his on-base percentage ranks first, and he is first in slugging.
• Isaac Paredes has 23 doubles, a triple, 18 home runs and 59 walks. He's batting .256 and slugging .421 with an on-base percentage of .355.
• His batting average ranks 65th among qualified players, his on-base percentage 35th, and his slugging percentage 67th.
• Paredes has picked up a hit in two straight games. During his last five outings he is hitting .118 with a home run, four walks and an RBI.
• Christian Walker has collected 112 base hits, an OBP of .302 and a slugging percentage of .427 this season.
• Jeremy Pena has been key for Houston with 99 hits, an OBP of .336 plus a slugging percentage of .477.

White Sox Player Leaders

• Miguel Vargas has 30 doubles, a triple, 29 home runs and 86 walks while batting .251. He's slugging .488 with an on-base percentage of .365.
• Including all qualifying players in the big leagues, his batting average puts him 79th, his on-base percentage ranks 24th, and he is 23rd in slugging.
• Vargas hopes to build on a three-game hitting streak in this matchup. During his last five outings he is batting .263 with four walks.
• Chase Meidroth is slugging .401 to pace his team. He has a batting average of .273 with an on-base percentage of .347.
• He is currently 39th in batting average, 45th in on-base percentage and 92nd in slugging percentage among all qualified hitters.
• Sam Antonacci has an on-base percentage of .366, a team-best for the White Sox.
• Tristan Peters is hitting .276 with 27 doubles, three triples, 12 home runs and 33 walks.

Astros vs White Sox Head to Head

• 9/1/2026: 5-1 CHW (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/31/2026: 6-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +118)
• 7/26/2026: 12-3 CHW (Favorite: White Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/25/2026: 4-1 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/24/2026: 9-5 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/12/2025: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 6/11/2025: 10-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/10/2025: 4-2 CHW (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 5/4/2025: 5-4 CHW (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/3/2025: 8-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -235, Underdog Moneyline: +194)

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