Astros vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 3

Odds updated as of 2:12 p.m.

The MLB slate on Thursday includes the Houston Astros taking on the Chicago White Sox.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Astros vs White Sox Game Info

• Houston Astros (71-69) vs. Chicago White Sox (73-66)
• Date: Thursday, September 3, 2026
• Time: 2:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and CHSN

Astros vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-142) | CHW: (+120)
• Spread: HOU: -1.5 (+146) | CHW: +1.5 (-178)
• Total: 8.5 -- Over: (-114) | Under: (-106)

Astros vs White Sox Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 4-3, 3.33 ERA vs Luis Castillo (White Sox) - 4-10, 5.31 ERA

The Astros will give the nod to Hunter Brown (4-3, 3.33 ERA), who is eyeing win No. 5 on the season, and the White Sox will counter with Luis Castillo (4-10, 5.31 ERA). Brown and his team have a record of 7-8-0 against the spread when he starts. Brown's team has a record of 6-7 this season when he starts and they are the favorite on the moneyline. The White Sox have an 8-14-0 ATS record in Castillo's 22 starts that had a set spread. The White Sox have a 3-6 record in Castillo's nine starts this season when they were the moneyline underdog.

Astros vs White Sox Moneyline

• The Astros vs White Sox moneyline has Houston as a -142 favorite, while Chicago is a +120 underdog on the road.

Astros vs White Sox Spread

• The White Sox are +1.5 on the run line against the Astros. The White Sox are -178 to cover, and the Astros are +146.

Astros vs White Sox Over/Under

• An over/under of 8.5 has been set for Astros-White Sox on Sept. 3, with the over being -114 and the under -106.

Bet on Houston Astros vs. Chicago White Sox on FanDuel today!

Astros vs White Sox Betting Trends

• The Astros have been chosen as favorites in 60 games this year and have walked away with the win 31 times (51.7%) in those games.
• Houston has a record of 9-17 in contests when oddsmakers favor them by -142 or more on the moneyline.
• The Astros' games have gone over the total in 72 of their 140 opportunities.
• The Astros are 68-72-0 against the spread in their 140 games with a line set by sportsbooks this season.
• The White Sox have won 49% of the games this season they were the underdog on the moneyline (49-51).
• When it has played as a moneyline underdog with odds of +120 or longer, Chicago has a record of 25-30 (45.5%).
• The White Sox have had an over/under set by oddsmakers 136 times, and have combined with opponents to go over the total in 75 of those games (75-60-1).
• The White Sox have collected a 79-57-0 record against the spread this season (covering 58.1% of the time).

Astros Player Leaders

• Yordan Alvarez leads Houston with 157 hits and an OBP of .433, plus a team-best slugging percentage of .604. He's batting .317.
• Among all qualified hitters in MLB, his batting average ranks first, his on-base percentage ranks first, and he is first in slugging.
• Isaac Paredes has 23 doubles, a triple, 18 home runs and 60 walks. He's batting .257 and slugging .420 with an on-base percentage of .356.
• He ranks 65th in batting average, 35th in on-base percentage and 71st in slugging among qualified hitters.
• Paredes brings a three-game streak with at least one hit into this one. During his last five outings he is hitting .167 with a home run, three walks and an RBI.
• Christian Walker has collected 112 base hits, an OBP of .301 and a slugging percentage of .425 this season.
• Jeremy Pena is batting .281 with a .335 OBP and 46 RBI for Houston this season.

White Sox Player Leaders

• Miguel Vargas has 30 doubles, a triple, 29 home runs and 86 walks while batting .249. He's slugging .484 with an on-base percentage of .363.
• Including all the qualified hitters in the big leagues, he is 84th in batting average, 25th in on-base percentage and 26th in slugging percentage.
• Chase Meidroth paces his team with a .399 slugging percentage. He has a batting average of .271 with an on-base percentage of .345.
• Including all qualified hitters, he ranks 42nd in batting average, 50th in on-base percentage and 95th in slugging percentage.
• Sam Antonacci a has .365 on-base percentage to pace the White Sox.
• Tristan Peters has 27 doubles, four triples, 12 home runs and 33 walks while batting .279.

Astros vs White Sox Head to Head

• 9/2/2026: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/1/2026: 5-1 CHW (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/31/2026: 6-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +118)
• 7/26/2026: 12-3 CHW (Favorite: White Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/25/2026: 4-1 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/24/2026: 9-5 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/12/2025: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 6/11/2025: 10-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/10/2025: 4-2 CHW (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 5/4/2025: 5-4 CHW (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)

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