Astros vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for AL Wild Card Game 1 on Sept. 29

Odds updated as of 11:12 p.m.

In MLB action on Tuesday, the Houston Astros face the Chicago White Sox for Game 1 of the AL Wild Card Series.

We've got you covered, in terms of the most important information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Astros vs White Sox Game Info

• Houston Astros (81-81) vs. Chicago White Sox (84-78)
• Date: Tuesday, September 29, 2026
• Time: 5 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: NBCSN and Peacock

Astros vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-126) | CHW: (+108)
• Spread: HOU: -1.5 (+155) | CHW: +1.5 (-188)
• Total: 8.5 -- Over: (+100) | Under: (-122)

Astros vs White Sox Probable Starting Pitchers

Probable Pitchers: A.J. Blubaugh (Astros) - 5-3, 3.66 ERA vs Hagen Smith (White Sox) - 3-3, 1.29 ERA

The Astros will call on A.J. Blubaugh (5-3, 3.66 ERA) versus the White Sox and Hagen Smith (3-3, 1.29 ERA). Blubaugh and his team were 2-1-0 ATS in games he pitched last year. Blubaugh and his team had a 1-1 record when he pitched as a favorite last season. Smith has started just one game with a set spread, which the White Sox failed to cover. The White Sox have not been a moneyline underdog when Smith starts this season.

Astros vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (53.4%)

Astros vs White Sox Moneyline

• Houston is a -126 favorite on the moneyline, while Chicago is a +108 underdog on the road.

Astros vs White Sox Spread

• The White Sox are at the Astros, and are +1.5 on the runline. The White Sox are +155 to cover the spread, and the Astros are -188.

Astros vs White Sox Over/Under

• The Astros-White Sox game on Sept. 29 has been given an over/under of 8.5 runs. The over is set at +100 and the under at -122.

Bet on Houston Astros vs. Chicago White Sox on FanDuel today!

Astros vs White Sox Betting Trends

• The Astros have been chosen as favorites in 72 games this year and have walked away with the win 38 times (52.8%) in those games.
• This year Houston has won 26 of 50 games when listed as at least -126 on the moneyline.
• The Astros and their opponents have gone over in 80 of their 162 games with a total set by sportsbooks this season.
• The Astros have posted a record of 82-80-0 against the spread this season.
• The White Sox have won 47.6% of the games this season they were the moneyline underdog (50-55).
• In games it has played as a moneyline underdog with odds of +108 or longer, Chicago has a record of 40-41 (49.4%).
• The White Sox have combined with opponents to hit the over on the total 89 times this season for an 89-69-1 record against the over/under.
• The White Sox are 90-69-0 ATS this season.

Astros Player Leaders

• Yordan Alvarez leads Houston in OBP (.432), slugging percentage (.601) and total hits (179) this season. He has a .316 batting average.
• Among all qualifying batters in MLB, he is first in batting average, first in on-base percentage, and first in slugging.
• Alvarez has recorded at least one hit in 12 games in a row. During his last 10 outings he is batting .395 with three doubles, three home runs, six walks and eight RBIs.
• Isaac Paredes is hitting .262 with 27 doubles, a triple, 25 home runs and 71 walks, while slugging .447 with an on-base percentage of .360.
• He is 56th in batting average, 30th in on-base percentage and 49th in slugging in MLB.
• Christian Walker is batting .226 with a .427 slugging percentage and 87 RBI this year.
• Walker brings a six-game hitting streak into this game. In his last 10 outings he is batting .263 with a double, four home runs, four walks and seven RBIs.
• Jeremy Pena has 22 home runs, 56 RBI and a batting average of .277 this season.
• Pena has safely hit in two straight games. In his last five games he is hitting .320 with two home runs and five RBIs.

White Sox Player Leaders

• Miguel Vargas is hitting .250 with 31 doubles, a triple, 33 home runs and 101 walks. He's slugging .474 with an on-base percentage of .363.
• Including all qualified hitters, he is 79th in batting average, while his on-base percentage ranks 24th and he is 30th in slugging.
• Chase Meidroth is slugging .415 to pace his team. He has a batting average of .276 with an on-base percentage of .350.
• He is currently 33rd in batting average, 45th in on-base percentage and 80th in slugging percentage among all qualified hitters.
• Sam Antonacci has racked up an on-base percentage of .370, a team-high for the White Sox.
• Munetaka Murakami leads his team with 94 hits.

Astros vs White Sox Head to Head

• 9/3/2026: 6-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 9/2/2026: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/1/2026: 5-1 CHW (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/31/2026: 6-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +118)
• 7/26/2026: 12-3 CHW (Favorite: White Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/25/2026: 4-1 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/24/2026: 9-5 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/12/2025: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 6/11/2025: 10-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/10/2025: 4-2 CHW (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)

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