Astros vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 6

Odds updated as of 10:12 p.m.

The Houston Astros will take on the Arizona Diamondbacks in MLB action on Sunday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this matchup.

Astros vs Diamondbacks Game Info

• Houston Astros (73-69) vs. Arizona Diamondbacks (74-68)
• Date: Sunday, September 6, 2026
• Time: 2:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and Dbacks.TV

Astros vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-110) | ARI: (-106)
• Spread: HOU: +1.5 (-182) | ARI: -1.5 (+150)
• Total: 8.5 -- Over: (+104) | Under: (-128)

Astros vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Peter Lambert (Astros) - 8-7, 3.66 ERA vs Eduardo Rodríguez (Diamondbacks) - 14-5, 2.59 ERA

The Astros will give the nod to Peter Lambert (8-7) versus the Diamondbacks and Eduardo Rodriguez (14-5). Lambert's team is 14-10-0 against the spread this season in his starts. Lambert's team is 7-4 this season when he starts and they are the moneyline favorite. When Rodriguez starts, the Diamondbacks are 18-10-0 against the spread. The Diamondbacks have been the moneyline underdog in 16 of Rodríguez's starts this season, and they went 12-4 in those matchups.

Astros vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (54.8%)

Astros vs Diamondbacks Moneyline

• Houston is the favorite, -110 on the moneyline, while Arizona is a -106 underdog on the road.

Astros vs Diamondbacks Spread

• The Diamondbacks are 1.5-run favorites against the spread for this matchup with the Astros. The Diamondbacks are +150 to cover, while the Astros are -182 to cover as a 1.5-run underdog on the runline.

Astros vs Diamondbacks Over/Under

• The Astros-Diamondbacks contest on Sept. 6 has been given an over/under of 8.5 runs. The over is set at +104 and the under at -128.

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Astros vs Diamondbacks Betting Trends

• The Astros have been chosen as favorites in 62 games this year and have walked away with the win 33 times (53.2%) in those games.
• This season Houston has been victorious 32 times in 61 chances when named as a favorite of at least -110 on the moneyline.
• The Astros and their opponents have gone over the total this season in 72 of their 142 opportunities.
• The Astros have posted a record of 70-72-0 against the spread this season.
• The Diamondbacks are 36-43 in games they were the underdog on the moneyline (winning 45.6% of those games).
• Arizona has a 35-44 record (winning 44.3% of its games) when it has played as a moneyline underdog of -106 or longer.
• The Diamondbacks have combined with opponents to go over the total 61 times this season for a 61-76-4 record against the over/under.
• The Diamondbacks have a 76-65-0 record against the spread this season (covering 53.9% of the time).

Astros Player Leaders

• Yordan Alvarez leads Houston with 159 hits and an OBP of .434, plus a team-best slugging percentage of .601. He's batting .317.
• Among qualifying batters in baseball, his batting average ranks second, his on-base percentage ranks first, and he is first in slugging.
• Isaac Paredes is hitting .258 with 25 doubles, a triple, 18 home runs and 61 walks, while slugging .423 with an on-base percentage of .358.
• Among all qualified, he is 64th in batting average, 31st in on-base percentage and 67th in slugging percentage.
• Paredes has picked up a hit in five games in a row. During his last five outings he is hitting .294 with two doubles, a home run, two walks and three RBIs.
• Christian Walker has collected 115 base hits, an OBP of .302 and a slugging percentage of .425 this season.
• Walker has picked up a hit in two straight games. During his last five outings he is hitting .188 with a walk and two RBIs.
• Jeremy Pena has been key for Houston with 101 hits, an OBP of .331 plus a slugging percentage of .467.

Diamondbacks Player Leaders

• Corbin Carroll is hitting .239 with 28 doubles, 16 triples, 19 home runs and 69 walks. He's slugging .466 with an on-base percentage of .335.
• Including all qualified hitters, he is 101st in batting average, while his on-base percentage ranks 64th and he is 35th in slugging.
• Geraldo Perdomo's .367 slugging percentage leads his team. He has a batting average of .252 with an on-base percentage of .359.
• He ranks 74th in batting average, 29th in on-base percentage and 121st in slugging percentage in the big leagues.
• Ketel Marte is hitting .251 with 24 doubles, three triples, 21 home runs and 43 walks.
• Gabriel Moreno's 119 hits and .379 OBP both pace his team.

Astros vs Diamondbacks Head to Head

• 9/4/2026: 3-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/23/2025: 4-3 HOU (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/22/2025: 3-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/21/2025: 6-3 HOU (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/8/2024: 12-6 ARI (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/7/2024: 11-5 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 9/6/2024: 8-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 10/1/2023: 8-1 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 9/30/2023: 1-0 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/29/2023: 2-1 HOU (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)

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