Astros vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 4

Odds updated as of 2:12 a.m.

The MLB's Friday schedule includes the Houston Astros facing the Arizona Diamondbacks.

We've got you covered, in terms of the most important info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Astros vs Diamondbacks Game Info

• Houston Astros (72-69) vs. Arizona Diamondbacks (74-67)
• Date: Friday, September 4, 2026
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and Dbacks.TV

Astros vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-136) | ARI: (+116)
• Spread: HOU: -1.5 (+164) | ARI: +1.5 (-200)
• Total: 8.5 -- Over: (-128) | Under: (+104)

Astros vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Cristian Javier (Astros) - 1-5, 6.45 ERA vs Merrill Kelly (Diamondbacks) - 9-12, 5.08 ERA

The Astros will give the ball to Cristian Javier (1-5, 6.45 ERA), who is eyeing win No. 2 on the season, and the Diamondbacks will turn to Merrill Kelly (9-12, 5.08 ERA). Javier's team is 2-6-0 against the spread in his starts this season. Javier's team has been victorious in 20% of the games he's started as the moneyline favorite with a record of 1-4. The Diamondbacks have gone 13-12-0 against the spread when Kelly starts. The Diamondbacks are 5-10 in Kelly's 15 starts this season that they were the moneyline underdog.

Astros vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (60.5%)

Astros vs Diamondbacks Moneyline

• Looking at the moneyline for Astros-Diamondbacks, Houston is the favorite at -136, and Arizona is +116 playing on the road.

Astros vs Diamondbacks Spread

• The Diamondbacks are +1.5 on the run line against the Astros. The Diamondbacks are -200 to cover, and the Astros are +164.

Astros vs Diamondbacks Over/Under

• Astros versus Diamondbacks, on Sept. 4, has an over/under of 8.5, with the over being -128 and the under +104.

Bet on Houston Astros vs. Arizona Diamondbacks on FanDuel today!

Astros vs Diamondbacks Betting Trends

• The Astros have been victorious in 32, or 52.5%, of the 61 contests they have been chosen as favorites in this season.
• Houston has a record of 13-19 in contests when sportsbooks favor them by -136 or more on the moneyline.
• The Astros and their opponents have gone over in 72 of their 141 games with a total set by sportsbooks this season.
• The Astros are 69-72-0 against the spread in their 141 games with a line set by sportsbooks this season.
• The Diamondbacks have been the underdog on the moneyline 78 total times this season. They've gone 36-42 in those games.
• Arizona is 20-22 (winning 47.6% of its games) when playing as a moneyline underdog of +116 or longer.
• The Diamondbacks have had an over/under set by bookmakers 140 times, and have combined with opponents to go over the total in 61 of those games (61-75-4).
• The Diamondbacks are 76-64-0 ATS this season.

Astros Player Leaders

• Yordan Alvarez has 157 hits and an OBP of .433 to go with a slugging percentage of .602. All three of those stats are best among Houston hitters this season. He has a .316 batting average, as well.
• Among all qualifying hitters in the majors, he ranks first in batting average, first in on-base percentage, and first in slugging.
• Isaac Paredes has 24 doubles, a triple, 18 home runs and 61 walks. He's batting .257 and slugging .422 with an on-base percentage of .357.
• Among qualified hitters, his batting average places him 65th, his on-base percentage 33rd, and his slugging percentage 66th.
• Paredes enters this game looking to extend his four-game hit streak. During his last five outings he is batting .222 with a double, a home run, three walks and two RBIs.
• Christian Walker has 114 hits this season and has a slash line of .228/.302/.426.
• Jeremy Pena is batting .278 with a .332 OBP and 46 RBI for Houston this season.

Diamondbacks Player Leaders

• Corbin Carroll is leading the Diamondbacks with 123 hits. He's batting .241 and slugging .470 with an on-base percentage of .337.
• He is 97th in batting average, 59th in on-base percentage and 32nd in slugging percentage among all qualified hitters in the big leagues.
• Geraldo Perdomo's .369 slugging percentage paces his team. He has a batting average of .253 with an on-base percentage of .360.
• Including all qualifying players, he is 73rd in batting average, 27th in on-base percentage and 118th in slugging percentage.
• Ketel Marte is batting .251 with 23 doubles, three triples, 21 home runs and 42 walks.
• Gabriel Moreno has a .376 on-base percentage to lead his team.

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