Astros vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 4

Odds updated as of 7:12 p.m.

The Houston Astros versus the Arizona Diamondbacks is on the MLB schedule for Friday.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Astros vs Diamondbacks Game Info

• Houston Astros (72-69) vs. Arizona Diamondbacks (74-67)
• Date: Friday, September 4, 2026
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and Dbacks.TV

Astros vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-108) | ARI: (-108)
• Spread: HOU: +1.5 (-164) | ARI: -1.5 (+136)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Astros vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Cristian Javier (Astros) - 1-5, 6.45 ERA vs Merrill Kelly (Diamondbacks) - 9-12, 5.08 ERA

This contest's pitching matchup is set, as the Astros will send Cristian Javier (1-5) to the mound, while Merrill Kelly (9-12) will get the nod for the Diamondbacks. Javier and his team are 2-6-0 ATS this season when he starts. Javier's team is 1-4 this season when he starts and they are the moneyline favorite. The Diamondbacks have gone 13-12-0 ATS in Kelly's 25 starts that had a set spread. The Diamondbacks are 5-10 in Kelly's 15 starts this season that they were the moneyline underdog.

Astros vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (60.6%)

Astros vs Diamondbacks Moneyline

• The moneyline numbers for Astros vs. Diamondbacks reveal Houston as the favorite (-108) and Arizona as the underdog (-108) on the road.

Astros vs Diamondbacks Spread

Astros vs Diamondbacks Over/Under

• An over/under of 8.5 has been set for Astros-Diamondbacks on Sept. 4, with the over being -110 and the under -110.

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Astros vs Diamondbacks Betting Trends

• The Astros have been chosen as favorites in 61 games this year and have walked away with the win 32 times (52.5%) in those games.
• This season Houston has been victorious 33 times in 66 chances when named as a favorite of at least -108 on the moneyline.
• The Astros' games have gone over the total in 72 of their 141 opportunities.
• The Astros are 69-72-0 against the spread in their 141 games that had a posted line this season.
• The Diamondbacks have compiled a 36-42 record in games they were the underdog on the moneyline (winning 46.2% of those games).
• Arizona has a 36-43 record (winning 45.6% of its games) when it has played as a moneyline underdog of -108 or longer.
• The Diamondbacks have had an over/under set by bookmakers 140 times, and have combined with opponents to go over the total in 61 of those games (61-75-4).
• The Diamondbacks have covered 54.3% of their games this season, going 76-64-0 ATS.

Astros Player Leaders

• Yordan Alvarez leads Houston with 157 hits and an OBP of .433, plus a team-best slugging percentage of .602. He's batting .316.
• Among all qualified hitters, he is first in batting average, his on-base percentage ranks first, and he is first in slugging.
• Isaac Paredes is hitting .257 with 24 doubles, a triple, 18 home runs and 61 walks. He's slugging .422 with an on-base percentage of .357.
• Among qualified batters, his batting average ranks him 65th, his on-base percentage 33rd, and his slugging percentage 66th.
• Paredes has picked up a hit in four straight games. In his last five games he is hitting .222 with a double, a home run, three walks and two RBIs.
• Christian Walker has 114 hits this season and has a slash line of .228/.302/.426.
• Jeremy Pena is batting .278 with a .332 OBP and 46 RBI for Houston this season.

Diamondbacks Player Leaders

• Corbin Carroll has collected 123 hits, a team-best for the Diamondbacks. He's batting .241 and slugging .470 with an on-base percentage of .337.
• Including all the qualified players in the majors, his batting average ranks 97th, his on-base percentage is 59th, and he is 32nd in slugging.
• Geraldo Perdomo paces his team with a .369 slugging percentage. He has a batting average of .253 with an on-base percentage of .360.
• He is currently 73rd in batting average, 26th in on-base percentage and 119th in slugging percentage among all qualifying batters.
• Ketel Marte has 23 doubles, three triples, 21 home runs and 42 walks while hitting .251.
• Gabriel Moreno's .376 OBP leads his team.

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