Astros vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 22

Odds updated as of 6:12 p.m.

Saturday's slate in the MLB includes a matchup between the Houston Astros and the Athletics.

We've got you covered, in terms of the most important information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Astros vs Athletics Game Info

• Houston Astros (65-64) vs. Athletics (49-80)
• Date: Saturday, August 22, 2026
• Time: 7:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and NBCS-CA

Astros vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-174) | OAK: (+162)
• Spread: HOU: -1.5 (+116) | OAK: +1.5 (-138)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Astros vs Athletics Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 3-3, 3.67 ERA vs Jacob Lopez (Athletics) - 5-4, 5.22 ERA

The Astros will give the ball to Hunter Brown (3-3, 3.67 ERA), who is eyeing win No. 4 on the season, and the Athletics will turn to Jacob Lopez (5-4, 5.22 ERA). Brown and his team are 6-7-0 ATS this season when he starts. Brown's team is 5-6 this season when he starts and they are the moneyline favorite. The Athletics have an 8-9-0 ATS record in Lopez's 17 starts that had a set spread. The Athletics have been the underdog on the moneyline in 15 of Lopez's starts this season, and they went 7-8 in those games.

Astros vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (56.3%)

Astros vs Athletics Moneyline

• The Astros vs Athletics moneyline has the Astros as a -174 favorite, while the Athletics are a +162 underdog on the road.

Astros vs Athletics Spread

• The Astros are 1.5-run favorites on the runline against the Athletics. The Astros are +116 to cover, while the Athletics are -138 to cover.

Astros vs Athletics Over/Under

• A combined run total of 8.5 has been set for Astros-Athletics on Aug. 22, with the over at -110 and the under at -110.

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Astros vs Athletics Betting Trends

• The Astros have been victorious in 28, or 50.9%, of the 55 contests they have been chosen as favorites in this season.
• This season, the Astros have come away with a win three times in eight chances when named as a favorite of at least -174 or shorter on the moneyline.
• The Astros and their opponents have hit the over in 68 of their 129 games with a total this season.
• The Astros have posted a record of 62-67-0 against the spread this season.
• The Athletics have won 35.9% of the games this season they were the moneyline underdog (33-59).
• The Athletics have a record of 4-9 when playing as a moneyline underdog with odds of +162 or longer (30.8%).
• The Athletics have combined with their opponents to hit the over on the total 64 times this season for a 64-63-2 record against the over/under.
• The Athletics have covered 45% of their games this season, going 58-71-0 against the spread.

Astros Player Leaders

• Yordan Alvarez leads Houston in OBP (.434), slugging percentage (.618) and total hits (147) this season. He has a .321 batting average.
• Among qualified hitters in MLB, he is second in batting average, first in on-base percentage, and first in slugging.
• Alvarez hopes to build on a three-game hitting streak in this matchup. In his last five games he is batting .313 with three doubles, a walk and two RBIs.
• Isaac Paredes is batting .262 with 23 doubles, a triple, 16 home runs and 50 walks, while slugging .426 with an on-base percentage of .356.
• Among qualified hitters, his batting average places him 61st, his on-base percentage 38th, and his slugging percentage 67th.
• Paredes enters this matchup looking to extend his three-game hit streak. In his last five games he is batting .333 with two doubles, four walks and an RBI.
• Christian Walker has collected 106 base hits, an OBP of .309 and a slugging percentage of .442 this season.
• Jeremy Pena has 14 home runs, 40 RBI and a batting average of .283 this season.

Athletics Player Leaders

• Jeff McNeil has 16 doubles, six home runs and 25 walks while batting .261. He's slugging .356 with an on-base percentage of .313.
• Zack Gelof has 12 doubles, a triple, 14 home runs and 20 walks while hitting .265. He's slugging .474 with an on-base percentage of .325.
• Lawrence Butler is hitting .216 with 13 doubles, a triple, 11 home runs and 45 walks.
• Carlos Cortes is batting .261 with 15 doubles, a triple, seven home runs and 27 walks.

Astros vs Athletics Head to Head

• 8/21/2026: 4-0 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +162)
• 6/7/2026: 5-0 OAK (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/6/2026: 13-2 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/5/2026: 5-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/5/2026: 12-10 OAK (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/4/2026: 11-0 HOU (Favorite: Athletics, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/3/2026: 11-4 OAK (Favorite: Athletics, Spread: -1.5, Total: 10, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/25/2025: 11-5 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/24/2025: 6-0 OAK (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/23/2025: 5-1 OAK (Favorite: Athletics, Spread: -1.5, Total: 10, Favorite Moneyline: -112, Underdog Moneyline: -104)

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