Astros vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 22

Odds updated as of 2:12 a.m.

The Houston Astros versus the Athletics is on the MLB schedule for Saturday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding this matchup.

Astros vs Athletics Game Info

• Houston Astros (65-64) vs. Athletics (49-80)
• Date: Saturday, August 22, 2026
• Time: 7:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and NBCS-CA

Astros vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-174) | OAK: (+162)
• Spread: HOU: -1.5 (+116) | OAK: +1.5 (-138)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Astros vs Athletics Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 3-3, 3.67 ERA vs Jacob Lopez (Athletics) - 5-4, 5.22 ERA

The Astros will give the nod to Hunter Brown (3-3) versus the Athletics and Jacob Lopez (5-4). Brown's team is 6-7-0 against the spread in his starts this season. Brown's team has won 45.5% of his starts when they are favored on the moneyline (5-6). The Athletics have an 8-9-0 record against the spread in Lopez's starts. The Athletics are 7-8 in Lopez's 15 starts this season that they were the underdog on the moneyline.

Astros vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (55.1%)

Astros vs Athletics Moneyline

• The Astros vs Athletics moneyline has the Astros as a -174 favorite, while the Athletics are a +162 underdog on the road.

Astros vs Athletics Spread

• The Astros are 1.5-run favorites on the runline against the Athletics. The Astros are +116 to cover, while the Athletics are -138 to cover.

Astros vs Athletics Over/Under

• The over/under for Astros-Athletics on Aug. 22 is 8.5. The over is -110, and the under is -110.

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Astros vs Athletics Betting Trends

• The Astros have come away with 28 wins in the 55 contests they have been listed as the favorites in this season.
• This year, the Astros have won three of eight games when listed as at least -174 or better on the moneyline.
• The Astros and their opponents have hit the over in 68 of their 129 games with a total this season.
• The Astros have posted a record of 62-67-0 against the spread this season.
• The Athletics have gone 33-59 in games they were listed as the moneyline underdog (winning 35.9% of those games).
• The Athletics have gone 4-9 when they have played as a moneyline underdog with odds of +162 or longer (30.8%).
• The Athletics have combined with their opponents to go over the total 64 times this season for a 64-63-2 record against the over/under.
• The Athletics are 58-71-0 ATS this season.

Astros Player Leaders

• Yordan Alvarez leads Houston in OBP (.434), slugging percentage (.618) and total hits (147) this season. He has a .321 batting average.
• He ranks second in batting average, first in on-base percentage, and first in slugging among qualifying hitters in MLB.
• Alvarez hopes to build on a three-game hitting streak in this matchup. During his last five outings he is batting .313 with three doubles, a walk and two RBIs.
• Isaac Paredes has 23 doubles, a triple, 16 home runs and 50 walks. He's batting .262 and slugging .426 with an on-base percentage of .356.
• Among all qualifying players, he ranks 61st in batting average, 39th in on-base percentage and 68th in slugging percentage.
• Paredes heads into this matchup looking to extend his three-game hit streak. During his last five outings he is hitting .333 with two doubles, four walks and an RBI.
• Christian Walker is batting .233 with a .442 slugging percentage and 72 RBI this year.
• Jeremy Pena has been key for Houston with 88 hits, an OBP of .338 plus a slugging percentage of .469.

Athletics Player Leaders

• Jeff McNeil is hitting .261 with 16 doubles, six home runs and 25 walks. He's slugging .356 with an on-base percentage of .313.
• Zack Gelof has 12 doubles, a triple, 14 home runs and 20 walks while batting .265. He's slugging .474 with an on-base percentage of .325.
• Lawrence Butler has 13 doubles, a triple, 11 home runs and 45 walks while hitting .216.
• Carlos Cortes has 15 doubles, a triple, seven home runs and 27 walks while batting .261.

Astros vs Athletics Head to Head

• 8/21/2026: 4-0 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +162)
• 6/7/2026: 5-0 OAK (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/6/2026: 13-2 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/5/2026: 5-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/5/2026: 12-10 OAK (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/4/2026: 11-0 HOU (Favorite: Athletics, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/3/2026: 11-4 OAK (Favorite: Athletics, Spread: -1.5, Total: 10, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/25/2025: 11-5 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/24/2025: 6-0 OAK (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/23/2025: 5-1 OAK (Favorite: Athletics, Spread: -1.5, Total: 10, Favorite Moneyline: -112, Underdog Moneyline: -104)

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