Alabama vs South Carolina Prediction, Odds, Picks, Best Bets for Week 4 2026

The Saturday schedule in college football includes a matchup between the Alabama Crimson Tide and the South Carolina Gamecocks.

We've got you covered, in terms of the most important information regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Alabama vs South Carolina Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Alabama: (-521) | South Carolina: (+385)
• Spread: Alabama: -12.5 (-110) | South Carolina: +12.5 (-110)
• Total: 53.5 -- Over: (-110) | Under: (-110)

Alabama vs South Carolina Betting Trends

• Alabama has two wins against the spread this season.
• Alabama has won once ATS (1-1) as a 12.5-point or higher favorite this year.
• Alabama and its opponent have not failed to hit the over in any game this season.
• South Carolina has but one win versus the spread this season.
• South Carolina has played two games (out of three) which finished over the total this season.

Alabama vs South Carolina Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Crimson Tide win (82.1%)

Alabama vs South Carolina Point Spread

Alabama is a 12.5-point favorite against South Carolina. Alabama is -110 to cover the spread, and South Carolina is -110.

Alabama vs South Carolina Over/Under

A total of 53.5 points has been set for the Alabama-South Carolina game on Sept. 26, with the over available at -110 and the under at -110.

Alabama vs South Carolina Moneyline

The moneyline numbers for Alabama vs. South Carolina reveal Alabama as the favorite (-521) and South Carolina as the underdog (+385).

Alabama vs. South Carolina Points Insights

Alabama vs. South Carolina Game Info

• Game day: Saturday, September 26, 2026
• Game time: 7 p.m. ET
• TV channel: ESPN
• Location: Tuscaloosa, Alabama
• Stadium: Bryant-Denny Stadium

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Check out even more in-depth Alabama vs. South Carolina analysis on FanDuel Research.