Alabama vs South Carolina Prediction, Odds, Picks, Best Bets for Week 4 2026

NCAA football action on Saturday includes the Alabama Crimson Tide facing the South Carolina Gamecocks.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

Alabama vs South Carolina Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Alabama: (-521) | South Carolina: (+385)
• Spread: Alabama: -12.5 (-110) | South Carolina: +12.5 (-110)
• Total: 54.5 -- Over: (-106) | Under: (-114)

Alabama vs South Carolina Betting Trends

• Alabama has posted two wins against the spread this year.
• As a 12.5-point or greater favorite, Alabama has one win ATS (1-1) this season.
• Alabama and its opponent have not failed to hit the over in any game this season.
• South Carolina has but one win versus the spread this season.
• Two South Carolina games (of three) have gone over the point total this season.

Alabama vs South Carolina Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Crimson Tide win (84%)

Alabama vs South Carolina Point Spread

Alabama is favored by 12.5 points over South Carolina. Alabama is -110 to cover the spread, with South Carolina being -110.

Alabama vs South Carolina Over/Under

A combined point total of 54.5 has been set for Alabama-South Carolina on Sept. 26, with the over at -106 and the under at -114.

Alabama vs South Carolina Moneyline

South Carolina is a +385 underdog on the moneyline, while Alabama is a -521 favorite.

Alabama vs. South Carolina Points Insights

Alabama vs. South Carolina Game Info

• Game day: Saturday, September 26, 2026
• Game time: 7 p.m. ET
• TV channel: ESPN
• Location: Tuscaloosa, Alabama
• Stadium: Bryant-Denny Stadium

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Check out even more in-depth Alabama vs. South Carolina analysis on FanDuel Research.