49ers vs Rams Prediction: 10 NFL Best Bets and Player Props for Thursday Night Australia

NFL Betting Picks & Player Props in Summary

• Rams -3.5
• Over 48.5
• Puka Nacua Over 90.5 Receiving Yards
• Christian McCaffrey Anytime Touchdown
• Kyren Williams Over 55.5 Rushing Yards
• Brock Purdy 2+ Passing Touchdowns
• Matthew Stafford Over 263.5 Passing Yards
• George Kittle Over 37.5 Receiving Yards
• Davante Adams Anytime Touchdown
• Kyren Williams or Christian McCaffrey Anytime Touchdown

The 49ers and Rams open the season Thursday night in Australia, and the prop board is loaded — Christian McCaffrey, Puka Nacua, Matthew Stafford and Brock Purdy all headline one of the deepest markets of the entire Week 1 slate.

All NFL odds come from FanDuel Sportsbook's NFL betting odds and may change after this article is published.

NFL Predictions and Picks

San Francisco 49ers at Los Angeles Rams (Thu, 8:35 p.m. ET)

Rams -3.5 (-114)

A modest home favorite in a genuine star-studded matchup, with Puka Nacua's own price to lead the game in receiving yards (-115) reflecting real confidence in a productive Rams passing attack.

Over 48.5 (-105)

The two team totals combine to 49 points on their own, essentially matching this number — a genuinely fair reflection of two rosters this loaded on skill talent.

Best Player Props

Puka Nacua Over 90.5 Receiving Yards (-114)

Nacua is priced at an almost unthinkable -10000 just to record a single 10-yard catch, and he's favored to lead the entire game in receiving yards — a genuine floor-and-ceiling combination in the opener.

Christian McCaffrey Anytime Touchdown (-155)

The shortest price on the entire touchdown board, and McCaffrey is also favored to lead the game outright in rushing yards over Kyren Williams — a genuine workhorse role to open the season.

Kyren Williams Over 55.5 Rushing Yards (-114)

Williams is tied for the second-shortest anytime touchdown price on this entire board at -130, a real sign of a genuine lead-back role for the Rams in the opener.

Brock Purdy 2+ Passing Touchdowns (-102)

Genuinely a coin-flip number for Purdy, with George Kittle, Deebo Samuel and Mike Evans all giving him real, distributed target options to find the end zone.

Matthew Stafford Over 263.5 Passing Yards (-114)

Stafford is also favored to lead the entire game in passing yards over Purdy, and with Nacua drawing this much volume, the number looks genuinely well-supported.

George Kittle Over 37.5 Receiving Yards (-114)

Kittle is priced to clear a single 10-yard catch at -1450, a genuine sign he remains a real, featured piece of San Francisco's passing attack alongside Deebo Samuel and Mike Evans.

Davante Adams Anytime Touchdown (+125)

Adams is tied for the third-shortest touchdown price on the board alongside Nacua, a real sign of red-zone confidence in Los Angeles's veteran receiver.

Kyren Williams or Christian McCaffrey Anytime Touchdown (-475)

Combining the two clear lead backs into a single bet is about as safe a touchdown play as this board offers, with both drawing genuine workhorse usage in the opener.