49ers vs Panthers Prediction, Odds, Picks, Best Bets for NFL Week 12 Monday Night Football

The NFL's Monday schedule includes the San Francisco 49ers taking on the Carolina Panthers.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NFL moneyline insights you need to know.

49ers vs Panthers Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: 49ers win (68%)

49ers vs Panthers Point Spread

The 49ers are 7-point favorites against the Panthers. The 49ers are -110 to cover the spread, while the Panthers are -110 to cover as a 7-point underdog.

49ers vs Panthers Over/Under

The 49ers-Panthers matchup on Nov. 24 has been given an over/under of 49.5 points. The over is -110 and the under is -110.

49ers vs Panthers Moneyline

San Francisco is a -370 favorite on the moneyline, while Carolina is a +295 underdog on the road.

49ers vs Panthers Betting Trends

• San Francisco is 6-5-0 against the spread this year.
• Out of 11 49ers games so far this year, seven have gone over the total.
• The Panthers have covered the spread seven times in 11 games.
• Carolina has won twice ATS (2-1) as a 7-point underdog or more this season.
• There have been six Panthers games (out of 11) that hit the over this year.

Check out even more in-depth 49ers vs. Panthers analysis on FanDuel Research.

49ers vs Panthers Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-370) | CAR: (+295)
• Spread: SF: -7 (-110) | CAR: +7 (-110)
• Total: 49.5 -- Over: (-110) | Under: (-110)

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