Astros vs Rays Prediction, Odds, Moneyline, Spread & Over/Under for May 21

Odds updated as of 12:11 p.m.

The MLB's Wednesday schedule includes the Houston Astros taking on the Tampa Bay Rays.

We've got you covered, in terms of the most important info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Astros vs Rays Game Info

• Houston Astros (25-23) vs. Tampa Bay Rays (22-26)
• Date: Wednesday, May 21, 2025
• Time: 1:10 p.m. ET
• Venue: George M. Steinbrenner Field -- Tampa, Florida
• Coverage: FDSSUN and SCHN

Astros vs Rays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-158) | TB: (+134)
• Spread: HOU: -1.5 (-100) | TB: +1.5 (-120)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Astros vs Rays Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 6-2, 1.43 ERA vs Taj Bradley (Rays) - 3-3, 4.80 ERA

The Astros will call on Hunter Brown (6-2) against the Rays and Taj Bradley (3-3). Brown's team is 7-2-0 against the spread in his starts this season. Brown's team has won 71.4% of his starts when they are favored on the moneyline (5-2). When Bradley starts, the Rays are 4-5-0 against the spread. The Rays are 2-1 in Bradley's three starts this season that they were the underdog on the moneyline.

Astros vs Rays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (56%)

Astros vs Rays Moneyline

• Houston is the favorite, -158 on the moneyline, while Tampa Bay is a +134 underdog despite being at home.

Astros vs Rays Spread

• The Rays are hosting the Astros, and are +1.5 on the runline. The Rays are -100 to cover the spread, and the Astros are -120.

Astros vs Rays Over/Under

• The over/under for Astros-Rays on May 21 is 8.5. The over is -115, and the under is -105.

Bet on Houston Astros vs. Tampa Bay Rays on FanDuel today!

Astros vs Rays Betting Trends

• The Astros have been favorites in 32 games this season and have come away with the win 18 times (56.2%) in those contests.
• Houston has a record of 4-4 in contests when sportsbooks favor them by -158 or more on the moneyline.
• The Astros and their opponents have gone over in 19 of their 48 games with a total set by sportsbooks this season.
• The Astros have an against the spread record of 26-22-0 in 48 games with a line this season.
• The Rays have won 10 of the 21 games they were listed as the moneyline underdog this season (47.6%).
• When playing as a moneyline underdog with odds of +134 or longer, Tampa Bay has a 4-6 record (winning 40% of its games).
• The Rays have had an over/under set by oddsmakers 47 times, and have combined with opponents to go over the total in 18 of those games (18-27-2).
• The Rays are 20-27-0 against the spread this season.

Astros Player Leaders

• Isaac Paredes has 46 hits and an OBP of .376, both of which lead Houston hitters this season. He has a .264 batting average and a slugging percentage of .448.
• Among all qualifying batters in the majors, he ranks 67th in batting average, 27th in on-base percentage, and 59th in slugging.
• Paredes will look for his sixth straight game with a hit in this contest. During his last five outings he is batting .300 with two home runs, two walks and six RBIs.
• Jeremy Pena leads Houston in slugging percentage (.445) thanks to 14 extra-base hits. He's batting .302 with an on-base percentage of .358.
• Among all qualifying hitters, he is 19th in batting average, 50th in on-base percentage and 62nd in slugging percentage.
• Jake Meyers has 43 hits this season and has a slash line of .307/.372/.436.
• Meyers has recorded at least one base hit in five games in a row. During his last five outings he is hitting .412 with a double, a home run, three walks and two RBIs.
• Jose Altuve is batting .242 with a .294 OBP and 14 RBI for Houston this season.

Rays Player Leaders

• Yandy Diaz has accumulated a slugging percentage of .400, a team-best for the Rays. He's batting .250 with an on-base percentage of .301.
• Including all the qualified players in MLB, his batting average is 91st, his on-base percentage is 117th, and he is 97th in slugging.
• Diaz hopes to build on a five-game hitting streak in this matchup. In his last five games he is hitting .350 with a double, a walk and four RBIs.
• Jonathan Aranda's 44 hits and .396 on-base percentage are both team-highs. He has a batting average of .310 while slugging .500.
• Including all qualified hitters, he ranks 10th in batting average, 10th in on-base percentage and 27th in slugging percentage.
• Junior Caminero is hitting .230 with six doubles, eight home runs and eight walks.
• Brandon Lowe is batting .223 with three doubles, seven home runs and 13 walks.

Astros vs Rays Head to Head

• 5/20/2025: 3-2 TB (Favorite: Rays, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/19/2025: 4-3 HOU (Favorite: Rays, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/14/2024: 2-1 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/13/2024: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/12/2024: 6-1 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/4/2024: 1-0 TB (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 8/3/2024: 6-1 TB (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/2/2024: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 7/30/2023: 8-2 TB (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/29/2023: 17-4 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)

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