White Sox vs Reds Prediction, Odds & Best Bet for May 5 (Hunter Greene Shines in Cincinnati Home Victory)

The Cincinnati Reds (13-18) will look to earn their seventh victory in their last 10 games when they host the Chicago White Sox (10-22) in the first matchup of their three-game series on Friday, May 5.

White Sox vs Reds Game Info

• Date: Friday, May 5, 2023
• Time: 6:40 PM ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Apple TV+

It has not been an ideal start to the season for either the White Sox or the Reds. Each team checks in with a record well under the .500 mark and at least 6.5 games back in their respective divisions. The good news is that Friday's game serves as an opportunity to get back on track and build momentum.

White Sox vs Reds Odds & Spread

• All MLB betting lines, odds and prop bets are from FanDuel Sportsbook.
• Moneyline: CHW: (-104) | CIN: (-112)
• Spread: CHW: -1.5 (+146) | CIN: +1.5 (-178)
• Total: 8.5 -- Over: (-124) | Under: (+102)

The Reds enter this contest as slight home favorites on the moneyline per FanDuel Sportsbook's odds. This 6:40 p.m. ET clash also features an over/under of 8.5 runs with the over being favored at -124 odds.

White Sox vs Reds Betting Trends

• The White Sox are 4-2 straight up in their last six games against Cincinnati.
• The total has hit the over in four of the White Sox's last six games.
• Cincinnati is 5-1 straight up in its last six games against an AL opponent.
• The total has hit the over in six of Cincinnati's last nine home games.

White Sox vs Reds Prediction & Pick

The White Sox are coming off an impressive series win as they took two of three games from the AL Central-leading Minnesota Twins, but it's worth noting those victories came in Chicago. The White Sox are a different team on the road as they have lost eight straight games by a combined 26 runs.

The pitching matchup doesn't do the White Sox any favors here, either. Chicago is sending veteran Lance Lynn to the mound, who has battled to an 0-4 record and 7.16 ERA across six starts this year. He has allowed at least 4 earned runs in four of those six starts, too, as not much is going his way.

The Reds will counter with an exciting young starter in Hunter Greene. The 23-year-old can hit triple digits with ease and owns a 2.89 ERA in six starts. He has also allowed only 1 earned run over his last 14.0 innings of work. I'll trust the Reds to start this series off with a victory in front of the home crowd.

Final Score Prediction: White Sox: 3 | Reds: 5

White Sox vs Reds Best Bet

There's a lot to like about Hunter Greenes' chances of tearing this lineup apart on Friday night. Not a single one of the White Sox hitters have faced the Reds' starter before, meaning his unique arsenal of pitches could confuse them early on. Greene has racked up at least 7 strikeouts in three of his six starts and is facing a Chicago lineup that averages 9.50 strikeouts per away game (No. 21 in MLB).

Bet: Hunter Greene Over 6.5 Strikeouts (-118)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.