White Sox vs Guardians Prediction, Odds & Best Bet for May 22 (Chicago Pounces on Cleveland's Pitching Struggles)

Chicago White Sox vs. Cleveland Guardians prediction, odds and betting insights for MLB regular season game.
Chicago White Sox vs. Cleveland Guardians prediction, odds and betting insights for MLB regular season game. / AP Photos/Julio Cortez

The Chicago White Sox (19-29) search for their fourth straight win when they begin a three-game series with the rival Cleveland Guardians (20-26) on Monday, May 22.

White Sox vs Guardians Game Info

  • Date: Monday, May 22, 2023
  • Time: 6:10 p.m. ET
  • Venue: Progressive Field -- Cleveland, Ohio
  • Coverage: MLB Extra Innings, NBC Sports Chicago, Bally Sports Great Lakes

The White Sox are feeling good about themselves after Sunday's 5-2 win over the Kansas City Royals marked their third consecutive victory. Meanwhile, the Guardians hope to avoid their fourth straight loss after a 2-1 defeat at the hands of the New York Mets less than 24 hours ago.

White Sox vs Guardians Odds & Spread

  • All MLB betting lines, odds and prop bets are from FanDuel Sportsbook.
  • Moneyline: CHW: (+108) | CLE: (-126)
  • Spread: CHW: +1.5 (-196) | CLE: -1.5 (+162)
  • Total: 9 -- Over: (-104) | Under: (-118)

The Guardians enter this contest as home favorites on the moneyline and spread per FanDuel Sportsbook's odds. This 6:10 p.m. ET clash also features an over/under of 9 runs with the Under being favored at -118 odds.

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White Sox vs Guardians Betting Trends

  • The White Sox are 4-1 straight up (SU) in their last five games against the AL Central.
  • Cleveland is 1-5 SU in its last six games.
  • The total has hit the Under in eight of the White Sox's last 10 games.
  • The total has hit the Under in five of Cleveland's last six home games against the White Sox.

White Sox vs Guardians Prediction & Pick

The White Sox's starting pitching situation is up in the air heading into this evening's contest. Mike Clevinger was supposed to be the club's starter, but the veteran arm was placed on the 15-day injured list yesterday. Having said that, Chicago likely has confidence in whoever will take the mound given that it's won five of its past six contests.

Meanwhile, the struggling Hunter Gaddis is listed as the Guardians' starter. The 25-year-old rookie hasn't found any success in the Majors thus far, going 0-1 with a 6.86 ERA in five games (four starts). This is also Gaddis' first MLB game in a month, so there's no telling how he'll look. After all, he only went 1-2 with a 5.12 ERA in four starts with Triple-A Columbus.

With momentum on their side, I like the White Sox's chances of winning tonight. It was only last week that they defeated the Guardians twice in three meetings, outscoring their AL Central rivals 16-8 along the way. Gaddis' pitching inconsistencies only make it tougher for the home team to win, too.

In what should be a close game, I'm taking the White Sox to emerge victorious.

Final Score Prediction: White Sox: 5 | Guardians: 3

White Sox vs Guardians Best Bet

With limited betting options available at the time of writing, I'm taking the Under on the 9-run total as the best bet. The Under is not only 8-2 in the White Sox's last 10 games but also 12-4 in Cleveland's previous 16 at home. Furthermore, five of the last six Chicago-Cleveland tilts at Progressive Field hit the Under, averaging just 5.7 runs in those meetings.

Considering how the two sides rank in the bottom 10 when it comes to runs scored in the MLB, don't fireworks tonight.

Bet: Under 9 Total Runs (-118)

Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

Game odds refresh periodically and are subject to change.