NFL - Odds & Predictions

Vikings vs Bills Prediction, Odds & Best Bet (Bills Mafia Boosts Buffalo to Victory)

Devon Platana
Minnesota Vikings vs Buffalo Bills prediction, odds and betting trends for NFL Week 10.
Minnesota Vikings vs Buffalo Bills prediction, odds and betting trends for NFL Week 10. / AP Photos/Joshua Bessex
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Vikings vs Bills Week 10 Game Info

2022 NFL Regular Season Game
Minnesota Vikings (7-1, 3-1 Away) vs. Buffalo Bills (6-2, 3-0 Home)
Date: Sunday, Nov. 13, 2022
Time: 1 p.m. ET
Venue: Highmark Stadium — Orchard Park, NY
Coverage: FOX

Week 10 of the 2022 NFL season includes some noteworthy showdowns, but few are as big as the battle between the Minnesota Vikings and Buffalo Bills. The Vikings enter the week with the NFC's second-best record, improving to 7-1 following a 20-17 win over the Washington Commanders.

At the same time, the Bills hope to rebound from their second defeat of the year — a 20-17 loss to the rival New York Jets. Buffalo has yet to lose at Highmark Stadium this season, though, making it interesting to see if Bills Mafia will be a factor in this week's outcome.

Vikings vs Bills Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: MIN: (+198) | BUF: (-240)
Spread: MIN: +6 (-110) | BUF: -6 (-110)
Total: 45.5 —Over: (-112) | Under: (-108)

The Bills enter this contest as clear favorites on the moneyline and spread on FanDuel Sportsbook's updated odds. This inter-conference clash also features a total of 45.5, which is average compared to the Week 10 totals.

Vikings vs Bills Prediction & Pick

A big reason why the Bills came up short last week was that quarterback Josh Allen couldn't get in a groove under center. The Jets have one of the better aerial defenses in the league, hence why Allen is likely breathing a sigh of relief that he gets to face the Vikings, who rank in the bottom 10 when it comes to both completions and passing yards allowed per game.

And while the Vikings have been solid, they've benefited from the eighth-easiest schedule, according to ESPN's Mike Clay back in May. The Philadelphia Eagles are the only true Super Bowl contender that Minnesota has faced thus far and Kevin O'Connell's squad ended up losing that game, 24-7.

The Bills also have yet to lose on their home turf. In fact, they're 19-4 straight up in their last 23 games at Highmark Stadium, having not lost on their own field since Dec. 6, 2021. On top of that, Buffalo boasts the NFL's best scoring offenses and defenses at home.

The Vikings also have had a harder time scoring the ball on the road. Though they average 24.1 PPG overall (No. 8) this season, that clip drops to just 19.8 PPG (12th-worst) in away games.

Taking the above nto account, I expect the Bills to get back on track with a victory this Sunday.

Final Score Prediction: Bills: 28 | Vikings: 21

Vikings vs Bills Betting Trends

- Minnesota is 1-4 straight up in its last five games against Buffalo.
- Buffalo is 11-4-1 against the spread (ATS) in its last 16 games played in November.
- The total has hit the under in four of Minnesota's last five road games against Buffalo
- The total has hit the under in each of Buffalo's last six games.

Vikings vs Bills Best Bet

At 7-1, it's tough to imagine the Vikings losing by more than six points, but I predict that'll happen this week. Minnesota was destroyed the last time that it faced an elite team, which also happened to be on the road. Additionally, the Bills are 4-2 against the spread in their last six games against the Vikings, which includes winning by 21 points in the last meeting four years ago.

Back the Bills covering the 6-point spread as they give the Vikings a huge dose of reality.

Bet: Bills -6 (-110)

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Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

Game odds refresh periodically and are subject to change.

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