USC vs Stanford Prediction, Odds & Betting Trends for College Football Week 2 Game on FanDuel

USC vs Stanford Week 2 Game Info

2022 NCAA College Football Game
No. 10 USC Trojans (1-0, 0-0 PAC-12) vs. Stanford Cardinal (1-0, 0-0 PAC-12)
Date: Saturday, Sept. 10, 2022
Time: 7:30 p.m. ET
Venue: Stanford Stadium — Stanford, CA
Coverage: ABC

Week 2 of the 2022 NCAA college football season includes a Pac-12 showdown in Palo Alto between the No. 10 USC Trojans and Stanford Cardinal. Last season, the Cardinal pulled the shocking road upset as 17-point underdogs to win 42-28 at Southern Cal.

USC vs Stanford Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: USC: (-330) | STAN: (+260)
Spread: USC: -7.5 (-115) | STAN: +7.5 (-105)
Total: 67.5 — Over: (-110) | Under: (-110)

USC is a -7.5 point road favorite and the high total is up to 67.5. This 7:30 p.m. ET feature is nationally televised on ABC.

USC vs Stanford Prediction & Pick

The Trojans rolled to a 66-14 win last week in coach Lincoln Riley's debut for Southern Cal. The Trojans returned 3 interceptions for touchdowns in the win over Rice, and USC quarterback Caleb Williams hit on 19 of his 22 attempts for 249 yards, while adding a team-leading 68 rushing yards.

Stanford QB Tanner McKee is a talented leader who passed for 308 yards last week on 22-of-27 completions including 87 yards to EJ Smith, son of former NFL great Emmitt. Smith also had 118 rushing yards in a 41-10 win over Colgate.

Stanford's defense will really need to step up and force turnovers to stay within reach. Full focus this week for USC after getting upset at home last year by Stanford.

Final Score Prediction: USC: 37 | Stanford: 23

USC vs Stanford Betting Trends

• USC is 2-6 ATS in their last 8 games.
• USC is 2-6 ATS in their last 8 games vs Stanford.
• The total has gone under in 4 of USC's last 5 games at Stanford.
• Stanford is 0-8 ATS in their last 8 games.
• Stanford is 0-5 ATS in their last 5 home games.

USC vs Stanford Best Bet

All NCAAF betting lines, odds and prop bets are available on FanDuel Sportsbook.

Stanford's scoring defense was worst in the Pac-12 last year allowing 32.4 points per game. USC is on a 5-0 ATS run as conference road favorite and full attention with USC the stronger team against Stanford.

Bet: USC -7.5 (-115)