Titans vs Bills Prediction, Odds & Betting Trends for NFL Week 2 Monday Night Football on FanDuel Sportsbook

Titans vs Bills Week 2 Game Info

2022 NFL Regular Season — Week 2 Monday Night Football Game
Tennessee Titans (0-1, 0-0 Away) vs. Buffalo Bills (1-0, 0-0 Home)
Date: Monday, September 19, 2022
Time: 7:15 p.m. ET
Venue: Highmark Stadium — Orchard Park, NY
Coverage: ESPN

The Tennessee Titans will look to avoid a dreaded 0-2 start when they visit the Buffalo Bills in Week 2 NFL action. The Titans dropped their home opener to the New York Giants by a score of 21-20 in Week 1. Running back Dontrell Hilliard's pair of receiving touchdowns weren't enough to earn a win.

Meanwhile, the Bills proved why they are the Super Bowl favorites with a 31-10 Week 1 victory over the Los Angeles Rams. Quarterback Josh Allen threw for 3 touchdowns and added another on on the ground. It was Buffalo's stellar defense that shined the most with 3 interceptions, though.

Titans vs Bills Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: TEN: (+340) | BUF: (-430)
Spread: TEN: +9.5 (-104) | BUF: -9.5 (-118)
Total: 49.5 — Over: (-108) | Under: (-112)

The Bills enter this contest as a clear favorite on the moneyline and the spread. This Monday night clash also features one of the higher projected totals (49.5) on the NFL Week 2 slate.

Titans vs Bills Prediction & Pick

It's hard to back anyone to defeat the Bills at this point. Their roster is stacked at nearly every position and now they get to play in front of their passionate home crowd. Buffalo has posted a 13-4 record at Highmark Stadium since the start of 2021 and averaged 28.4 points per game at home last year.

Buffalo looked unstoppable on defense in the season opener and forced quarterback Matthew Stafford to make throws he didn't want to make. That does not bode well for Ryan Tannehill, who threw for 0 touchdowns and 1 interception against the Bills in 2021. Buffalo will roll at home.

Final Score Prediction: Titans: 17 | Bills: 31

Titans vs Bills Betting Trends

- Tennessee is 10-4 straight up in its last 14 games against Buffalo.
- The total has hit the over in 12 of Tennessee's last 15 away games.
- Buffalo is 5-2 against the spread (ATS) in its last seven games in September.
- The total has hit the over in seven of Buffalo's last 10 Week 2 games.

Titans vs Bills Best Bet

All NFL betting lines, odds and prop bets are available on FanDuel Sportsbook.

This is a matchup between two teams that performed very differently in Week 1. The Titans went into halftime with a 13-0 lead before giving up 21 second-half points to the New York Giants. On the other side, the Bills went into halftime tied before outscoring the Rams by 21 points in the second half.

The presence of running back Derrick Henry should allow the Titans to slow down the clock and keep this game within one possession at halftime. The second half is a whole other beast, though. That is when Allen thrives the most, so back the Bills to cushion their lead with a big second half performance.

Bet: 2nd Half Spread: Bills -4.5 (-110)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.